Perinatal development of innate immune topology

Philipp Henneke; Katrin Kierdorf; Lindsay J. Hall; Markus Sperandio; Mathias Hornef

doi:10.7554/eLife.67793

Perinatal development of innate immune topology

Philipp Henneke^*, Katrin Kierdorf, Lindsay J. Hall, Markus Sperandio, Mathias Hornef^*

^*Corresponding author for this work

Microbiology and Infection

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

13 Downloads (Pure)

Abstract

At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory mechanisms and adaptation to changes in the tissue microenvironment. Overall, longer developmental trajectories are intersected by events related to mother-infant separation, birth cues, acquisition of microbiota and metabolic factors. Perinatal alterations particularly affect immune niches, where structures with discrete functions meet, the intestinal mucosa, epidermis and lung. Accordingly, the following questions will be addressed in this review:

How does the preprogrammed development supported by endogenous cues, steer innate immune cell differentiation, adaptation to tissue structures, and immunity to infection?

How does the transition at birth impact on tissue immune make-up including its topology?

How do postnatal cues guide innate immune cell differentiation and function at immunological niches?

Original language	English
Article number	e67793
Number of pages	21
Journal	eLife
Volume	10
DOIs	https://doi.org/10.7554/eLife.67793
Publication status	Published - 25 May 2021

Bibliographical note

Funding Information:
Funder Grant reference number Author Bundesministerium für Bildung und Forschung Deutsche Forschungsgemeinschaft Deutsche Forschungsge-meinschaft 01GL1746A SFB-TRR 167 SPP2225 Ho 2236/18-1 Philipp Henneke Philipp Henneke Mathias Hornef Deutsche Forschungsge-SFB1382 ID403224013 Mathias Hornef Deutsche Forschungsge-meinschaft Ho 2236/17-1 Mathias Hornef The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Publisher Copyright:
© Henneke et al.

ASJC Scopus subject areas

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

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HennekeP2021PerinatalFinal published version, 716 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Perinatal development of innate immune topology",

abstract = "At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory mechanisms and adaptation to changes in the tissue microenvironment. Overall, longer developmental trajectories are intersected by events related to mother-infant separation, birth cues, acquisition of microbiota and metabolic factors. Perinatal alterations particularly affect immune niches, where structures with discrete functions meet, the intestinal mucosa, epidermis and lung. Accordingly, the following questions will be addressed in this review: How does the preprogrammed development supported by endogenous cues, steer innate immune cell differentiation, adaptation to tissue structures, and immunity to infection? How does the transition at birth impact on tissue immune make-up including its topology? How do postnatal cues guide innate immune cell differentiation and function at immunological niches?",

author = "Philipp Henneke and Katrin Kierdorf and Hall, {Lindsay J.} and Markus Sperandio and Mathias Hornef",

note = "Funding Information: Funder Grant reference number Author Bundesministerium f{\"u}r Bildung und Forschung Deutsche Forschungsgemeinschaft Deutsche Forschungsge-meinschaft 01GL1746A SFB-TRR 167 SPP2225 Ho 2236/18-1 Philipp Henneke Philipp Henneke Mathias Hornef Deutsche Forschungsge-SFB1382 ID403224013 Mathias Hornef Deutsche Forschungsge-meinschaft Ho 2236/17-1 Mathias Hornef The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Henneke et al.",

year = "2021",

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doi = "10.7554/eLife.67793",

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AU - Henneke, Philipp

AU - Kierdorf, Katrin

AU - Hall, Lindsay J.

AU - Sperandio, Markus

AU - Hornef, Mathias

N1 - Funding Information: Funder Grant reference number Author Bundesministerium für Bildung und Forschung Deutsche Forschungsgemeinschaft Deutsche Forschungsge-meinschaft 01GL1746A SFB-TRR 167 SPP2225 Ho 2236/18-1 Philipp Henneke Philipp Henneke Mathias Hornef Deutsche Forschungsge-SFB1382 ID403224013 Mathias Hornef Deutsche Forschungsge-meinschaft Ho 2236/17-1 Mathias Hornef The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: © Henneke et al.

PY - 2021/5/25

Y1 - 2021/5/25

N2 - At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory mechanisms and adaptation to changes in the tissue microenvironment. Overall, longer developmental trajectories are intersected by events related to mother-infant separation, birth cues, acquisition of microbiota and metabolic factors. Perinatal alterations particularly affect immune niches, where structures with discrete functions meet, the intestinal mucosa, epidermis and lung. Accordingly, the following questions will be addressed in this review: How does the preprogrammed development supported by endogenous cues, steer innate immune cell differentiation, adaptation to tissue structures, and immunity to infection? How does the transition at birth impact on tissue immune make-up including its topology? How do postnatal cues guide innate immune cell differentiation and function at immunological niches?

AB - At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory mechanisms and adaptation to changes in the tissue microenvironment. Overall, longer developmental trajectories are intersected by events related to mother-infant separation, birth cues, acquisition of microbiota and metabolic factors. Perinatal alterations particularly affect immune niches, where structures with discrete functions meet, the intestinal mucosa, epidermis and lung. Accordingly, the following questions will be addressed in this review: How does the preprogrammed development supported by endogenous cues, steer innate immune cell differentiation, adaptation to tissue structures, and immunity to infection? How does the transition at birth impact on tissue immune make-up including its topology? How do postnatal cues guide innate immune cell differentiation and function at immunological niches?

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JO - eLife

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Perinatal development of innate immune topology

Abstract

Bibliographical note

ASJC Scopus subject areas

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