Perinatal development of innate immune topology

Philipp Henneke*, Katrin Kierdorf, Lindsay J. Hall, Markus Sperandio, Mathias Hornef*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
19 Downloads (Pure)


At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory mechanisms and adaptation to changes in the tissue microenvironment. Overall, longer developmental trajectories are intersected by events related to mother-infant separation, birth cues, acquisition of microbiota and metabolic factors. Perinatal alterations particularly affect immune niches, where structures with discrete functions meet, the intestinal mucosa, epidermis and lung. Accordingly, the following questions will be addressed in this review:

How does the preprogrammed development supported by endogenous cues, steer innate immune cell differentiation, adaptation to tissue structures, and immunity to infection?

How does the transition at birth impact on tissue immune make-up including its topology?

How do postnatal cues guide innate immune cell differentiation and function at immunological niches?

Original languageEnglish
Article numbere67793
Number of pages21
Publication statusPublished - 25 May 2021

Bibliographical note

Funding Information:
Funder Grant reference number Author Bundesministerium für Bildung und Forschung Deutsche Forschungsgemeinschaft Deutsche Forschungsge-meinschaft 01GL1746A SFB-TRR 167 SPP2225 Ho 2236/18-1 Philipp Henneke Philipp Henneke Mathias Hornef Deutsche Forschungsge-SFB1382 ID403224013 Mathias Hornef Deutsche Forschungsge-meinschaft Ho 2236/17-1 Mathias Hornef The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Publisher Copyright:
© Henneke et al.

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology


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