PARP Inhibitors: Staying on Target?

Craig L Doig; Gareth G Lavery

doi:10.1016/j.chembiol.2016.12.003

PARP Inhibitors: Staying on Target?

Craig L Doig, Gareth G Lavery

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Abstract

Successful phase III trials with poly-ADP-ribose (PARP) inhibitors will have implications for stratified cancer therapy. In this issue of Cell Chemical Biology, Knezevic et al. (2016) demonstrate that the existing collection of PARP inhibitors each display distinctive protein interaction profiles, reaching beyond their intended therapeutic target, with implications for metabolic and other disease.

Original language	English
Pages (from-to)	1442-1443
Number of pages	2
Journal	Cell Chemical Biology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.chembiol.2016.12.003
Publication status	Published - 22 Dec 2016

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Doig_et_al_PARP_inhibitors_Cell_Chemical_Biology_2016Accepted author manuscript, 416 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

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title = "PARP Inhibitors: Staying on Target?",

abstract = "Successful phase III trials with poly-ADP-ribose (PARP) inhibitors will have implications for stratified cancer therapy. In this issue of Cell Chemical Biology, Knezevic et al. (2016) demonstrate that the existing collection of PARP inhibitors each display distinctive protein interaction profiles, reaching beyond their intended therapeutic target, with implications for metabolic and other disease.",

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AU - Lavery, Gareth G

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JO - Cell Chemical Biology

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PARP Inhibitors: Staying on Target?

Abstract

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