Outcomes after liver transplantation of patients with Indo-Asian ethnicity

Chiara Rocha, M Thamara Perera, Keith Roberts, Glenn Bonney, Bridget Gunson, Peter Nightingale, Simon R Bramhall, John Isaac, Paolo Muiesan, Darius F Mirza

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


BACKGROUND: The impact of ethnicity on outcomes after orthotopic liver transplantation (OLT) is unclear. The British Indo-Asian population has a high incidence of liver disease but its contribution to the national deceased donor pool is small. We evaluated access to and outcomes of OLT in Indo-Asians.

METHODS: We compared 182 Indo-Asians with white patients undergoing OLT. Matching criteria were transplantation year, liver disease, age, sex. Donor and recipient characteristics, postoperative outcomes, including patient and graft survival, OLT era (early, 1987-2001; late, 2002-2011) were compared. Survival was also analyzed by underlying disease-acute liver failure (ALF) and chronic liver failure.

RESULTS: Indo-Asians had higher diabetes incidence. There were no differences in waiting time for transplantation, despite smaller body size and more uncommon blood groups (B, AB) among Indo-Asians. In the early era, patient survival for Indo-Asians with ALF was worse when compared to whites. In the late era, graft and patient survival at 1, 2, and 5 years were similar between groups.

CONCLUSION: This study demonstrates that Indo-Asian patients have equal access to OLT and comparable outcomes to whites in the United Kingdom. Survival has improved among Indo-Asian patients; this may be attributable to careful patient selection in case of ALF, though improvement of patient management may have contributed.

Original languageEnglish
Pages (from-to)860-6
Number of pages7
Issue number4
Publication statusPublished - Apr 2015


  • Adolescent
  • Adult
  • Aged
  • Asian Continental Ancestry Group
  • Chi-Square Distribution
  • Databases, Factual
  • End Stage Liver Disease
  • England
  • European Continental Ancestry Group
  • Female
  • Graft Survival
  • Health Services Accessibility
  • Healthcare Disparities
  • Humans
  • Incidence
  • India
  • Kaplan-Meier Estimate
  • Liver Failure, Acute
  • Liver Transplantation
  • Male
  • Middle Aged
  • Odds Ratio
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Waiting Lists
  • Young Adult


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