Abstract
BACKGROUND: The impact of ethnicity on outcomes after orthotopic liver transplantation (OLT) is unclear. The British Indo-Asian population has a high incidence of liver disease but its contribution to the national deceased donor pool is small. We evaluated access to and outcomes of OLT in Indo-Asians.
METHODS: We compared 182 Indo-Asians with white patients undergoing OLT. Matching criteria were transplantation year, liver disease, age, sex. Donor and recipient characteristics, postoperative outcomes, including patient and graft survival, OLT era (early, 1987-2001; late, 2002-2011) were compared. Survival was also analyzed by underlying disease-acute liver failure (ALF) and chronic liver failure.
RESULTS: Indo-Asians had higher diabetes incidence. There were no differences in waiting time for transplantation, despite smaller body size and more uncommon blood groups (B, AB) among Indo-Asians. In the early era, patient survival for Indo-Asians with ALF was worse when compared to whites. In the late era, graft and patient survival at 1, 2, and 5 years were similar between groups.
CONCLUSION: This study demonstrates that Indo-Asian patients have equal access to OLT and comparable outcomes to whites in the United Kingdom. Survival has improved among Indo-Asian patients; this may be attributable to careful patient selection in case of ALF, though improvement of patient management may have contributed.
Original language | English |
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Pages (from-to) | 860-6 |
Number of pages | 7 |
Journal | Transplantation |
Volume | 99 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2015 |
Keywords
- Adolescent
- Adult
- Aged
- Asian Continental Ancestry Group
- Chi-Square Distribution
- Databases, Factual
- End Stage Liver Disease
- England
- European Continental Ancestry Group
- Female
- Graft Survival
- Health Services Accessibility
- Healthcare Disparities
- Humans
- Incidence
- India
- Kaplan-Meier Estimate
- Liver Failure, Acute
- Liver Transplantation
- Male
- Middle Aged
- Odds Ratio
- Proportional Hazards Models
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Waiting Lists
- Young Adult