Our FABulous VACation: a decade of phosphatidylinositol 3,5-bisphosphate

Stephen Dove, Zoe Johnson

Research output: Contribution to journalReview article

15 Citations (Scopus)


PtdIns(3,5)P-2 was discovered about a decade ago and much of the machinery that makes, degrades and senses it lids been uncovered. Despite this, we still lack a complete understanding of how the pieces fit together but some patterns are beginning to emerge. Molecular functions for PtdIns(3,5)P-2 are also elusive, but the identification of effectors offers away into some of these processes. An examination of the defects associated with loss of synthesis of PtdIns(3,5)P2 in lower and higher eukaryotes begins to suggest a unifying theme; this lipid regulates membrane retrieval via retrograde trafficking from distal compartments to organelles that are more proximal in the endocytic/lysosomal system. Another unifying theme is stress signalling to organelles, possibly both to change their morphology in response to external insults and to maintain the lumenal pH or membrane potential of organelles. The next few years seem likely to uncover details of the molecular mechanisms underlying the biology of this fascinating lipid. This review also highlights some areas where further research is needed.
Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalBiochemical Society. Symposia
Publication statusPublished - 1 Dec 2007


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