Projects per year
Abstract
An outbreak caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
Original language | English |
---|---|
Pages (from-to) | 718-724 |
Number of pages | 7 |
Journal | New England Journal of Medicine |
Volume | 365 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Aug 2011 |
Fingerprint
Dive into the research topics of 'Open-Source Genomic Analysis of Shiga-Toxin-Producing E. coli O104:H4'. Together they form a unique fingerprint.Projects
- 1 Finished
-
xBASE: A bioinformatics resource for the AgriFood Bacteriology Community
Pallen, M. (Principal Investigator) & Stekel, D. (Co-Investigator)
Biotechnology & Biological Sciences Research Council
1/02/07 → 31/01/12
Project: Research Councils