TY - JOUR
T1 - Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta-analysis of English-language literature
AU - Ramakrishnan, Yujay
AU - Drinnan, Mike
AU - Kwong, Foon Ng Kee
AU - Grant, David G.
AU - Mehanna, Hisham
AU - Jones, Terry
AU - Paleri, Vinidh
PY - 2014/2
Y1 - 2014/2
N2 - BACKGROUND: The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer.\n\nMETHODS: The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease-free survival (DFS), and overall survival (OS) rates were calculated.\n\nRESULTS: The pooled mean estimates were: local control rate at 24 months after first TLM (n = 249), 56.9% (95% confidence interval [CI], 47.4-66.1); local control after repeat TLM (n = 186), 63.8% (95% CI, 57.1-70.2); DFS (n = 174), 70.9% (95% CI, 60.8-80); and OS (n = 276), 74.8% (95% CI, 68.2-80.9). Pooled mean laryngeal preservation (n = 286) was 72.3% (95% CI, 68.4-76.1).\n\nCONCLUSION: TLM is oncologically sound in the salvage setting with high larynx-preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques.
AB - BACKGROUND: The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer.\n\nMETHODS: The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease-free survival (DFS), and overall survival (OS) rates were calculated.\n\nRESULTS: The pooled mean estimates were: local control rate at 24 months after first TLM (n = 249), 56.9% (95% confidence interval [CI], 47.4-66.1); local control after repeat TLM (n = 186), 63.8% (95% CI, 57.1-70.2); DFS (n = 174), 70.9% (95% CI, 60.8-80); and OS (n = 276), 74.8% (95% CI, 68.2-80.9). Pooled mean laryngeal preservation (n = 286) was 72.3% (95% CI, 68.4-76.1).\n\nCONCLUSION: TLM is oncologically sound in the salvage setting with high larynx-preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques.
KW - glottis cancer
KW - meta-analysis
KW - radiorecurrent laryngeal carcinoma
KW - radiotherapy
KW - transoral laser microsurgery
UR - http://www.mendeley.com/research/oncologic-outcomes-transoral-laser-microsurgery-radiorecurrent-laryngeal-carcinoma-systematic-review
U2 - 10.1002/hed.23291
DO - 10.1002/hed.23291
M3 - Article
C2 - 23766141
SN - 1043-3074
VL - 36
SP - 280
EP - 285
JO - Head & Neck
JF - Head & Neck
IS - 2
ER -
