Oncogenic IDH1 mutations promote enhanced proline synthesis through PYCR1 to support the maintenance of mitochondrial redox homeostasis

Kate Hollinshead, Haydn Munford, Katherine Eales, Chiara Bardella, Chunjie Li, Cristina Escribano Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David Hodson, Wei Hua, Ian Tomlinson, Christian LudwigYing Mao, Daniel Tennant

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Medicine & Life Sciences

Chemistry