Ocular Syphilis Unmasked Following Intravitreal Triamcinolone Injection

B Mushtaq, R Gupta, Samer Elsherbiny, Philip Murray

Research output: Contribution to journalArticle

13 Citations (Scopus)


Purpose: To report intravitreal triamcinolone (IVTA)-induced unmasking of ocular syphilis. Design: Two case reports. Methods: A homosexual, diabetic male with macular edema treated with bilateral IVTA and a male with bilateral panuveitis and macular edema who underwent vitrectomy and IVTA. Both developed occlusive retinal vasculitis and panuveitis postinjection. Syphilis serology was positive although both denied previous symptoms. Results: Intramuscular penicillin lead to resolution of inflammation but both sustained severe loss of vision. Cause-and-effect relationship demonstrated between IVTA and reactivation of syphilis. Conclusions: Intravitreal corticosteroid can modulate the immune response to intraocular syphilis; vigilance is required, particularly in high-risk patients.
Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalOcular immunology and inflammation
Issue number3
Publication statusPublished - 1 Jan 2009


  • uveitis
  • retinal vasculitis
  • ocular syphilis
  • diabetes
  • intravitreal triamcinolone injection


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