Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults

Lian He; Wesley B. Baker; Daniel Milej; Venkaiah C. Kavuri; Rickson C. Mesquita; David R. Busch; Kenneth Abramson; Jane Y. Jiang; Mamadou Diop; Keith St Lawrence; Olivia Amendolia; Francis Quattrone; Ramani Balu; W. Andrew Kofke; Arjun G. Yodha

doi:10.1117/1.NPh.5.4.045006

Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults

Lian He^*, Wesley B. Baker, Daniel Milej, Venkaiah C. Kavuri, Rickson C. Mesquita, David R. Busch, Kenneth Abramson, Jane Y. Jiang, Mamadou Diop, Keith St Lawrence, Olivia Amendolia, Francis Quattrone, Ramani Balu, W. Andrew Kofke, Arjun G. Yodha

^*Corresponding author for this work

Computer Science

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green. A calibration coefficient (?) for the CBF is thus determined, permitting conversion of DCS BFI to absolute blood flow units at all other times. A study of patients with acute brain injury (N 7) is carried out to ascertain the stability of ?. The patientaveraged DCS calibration coefficient across multiple monitoring days and multiple patients was determined, and good agreement between the two calibration coefficients measured at different times during single monitoring days was found. The patient-averaged calibration coefficient of 1.24 × 109 omL/100 g/ min/ocm2/sp was applied to previously measured DCS BFI from similar brain-injured patients; in this case, absolute CBF was underestimated compared with XeCT, an effect we show is primarily due to use of semi-infinite homogeneous models of the head.

Original language	English
Article number	045006
Journal	Neurophotonics
Volume	5
Issue number	4
DOIs	https://doi.org/10.1117/1.NPh.5.4.045006
Publication status	Published - 1 Oct 2018

Bibliographical note

Funding Information:
We gratefully acknowledge Eileen Maloney, Elizabeth Mahanna, Suzanne Frangos, and Timothy Prior from Neurosurgery Clinical Research Division for clinical support. We thank Riley Wilson from 3M for sending us the double-sided tape. We thank Andre Liemert for providing the two-layer TR-NIRS forward solver. We acknowledge support from the National Institutes of Health (R01-NS082309-01A1, R01-NS060653, and P41-EB015893).

Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License 2017.

Keywords

absolute cerebral blood flow
brain-injured patients
continuous monitoring.
diffuse correlation spectroscopy
time-resolved contrast-enhanced near-infrared spectroscopy

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1117/1.NPh.5.4.045006

Cite this

He, L., Baker, W. B., Milej, D., Kavuri, V. C., Mesquita, R. C., Busch, D. R., Abramson, K., Jiang, J. Y., Diop, M., Lawrence, K. S., Amendolia, O., Quattrone, F., Balu, R., Kofke, W. A., & Yodha, A. G. (2018). Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults. Neurophotonics, 5(4), Article 045006. https://doi.org/10.1117/1.NPh.5.4.045006

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abstract = "We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green. A calibration coefficient (?) for the CBF is thus determined, permitting conversion of DCS BFI to absolute blood flow units at all other times. A study of patients with acute brain injury (N 7) is carried out to ascertain the stability of ?. The patientaveraged DCS calibration coefficient across multiple monitoring days and multiple patients was determined, and good agreement between the two calibration coefficients measured at different times during single monitoring days was found. The patient-averaged calibration coefficient of 1.24 × 109 omL/100 g/ min/ocm2/sp was applied to previously measured DCS BFI from similar brain-injured patients; in this case, absolute CBF was underestimated compared with XeCT, an effect we show is primarily due to use of semi-infinite homogeneous models of the head.",

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note = "Funding Information: We gratefully acknowledge Eileen Maloney, Elizabeth Mahanna, Suzanne Frangos, and Timothy Prior from Neurosurgery Clinical Research Division for clinical support. We thank Riley Wilson from 3M for sending us the double-sided tape. We thank Andre Liemert for providing the two-layer TR-NIRS forward solver. We acknowledge support from the National Institutes of Health (R01-NS082309-01A1, R01-NS060653, and P41-EB015893). Publisher Copyright: {\textcopyright} The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License 2017.",

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AU - He, Lian

AU - Baker, Wesley B.

AU - Milej, Daniel

AU - Kavuri, Venkaiah C.

AU - Mesquita, Rickson C.

AU - Busch, David R.

AU - Abramson, Kenneth

AU - Jiang, Jane Y.

AU - Diop, Mamadou

AU - Lawrence, Keith St

AU - Amendolia, Olivia

AU - Quattrone, Francis

AU - Balu, Ramani

AU - Kofke, W. Andrew

AU - Yodha, Arjun G.

N1 - Funding Information: We gratefully acknowledge Eileen Maloney, Elizabeth Mahanna, Suzanne Frangos, and Timothy Prior from Neurosurgery Clinical Research Division for clinical support. We thank Riley Wilson from 3M for sending us the double-sided tape. We thank Andre Liemert for providing the two-layer TR-NIRS forward solver. We acknowledge support from the National Institutes of Health (R01-NS082309-01A1, R01-NS060653, and P41-EB015893). Publisher Copyright: © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License 2017.

PY - 2018/10/1

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N2 - We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green. A calibration coefficient (?) for the CBF is thus determined, permitting conversion of DCS BFI to absolute blood flow units at all other times. A study of patients with acute brain injury (N 7) is carried out to ascertain the stability of ?. The patientaveraged DCS calibration coefficient across multiple monitoring days and multiple patients was determined, and good agreement between the two calibration coefficients measured at different times during single monitoring days was found. The patient-averaged calibration coefficient of 1.24 × 109 omL/100 g/ min/ocm2/sp was applied to previously measured DCS BFI from similar brain-injured patients; in this case, absolute CBF was underestimated compared with XeCT, an effect we show is primarily due to use of semi-infinite homogeneous models of the head.

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Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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