Projects per year
Abstract
Parkinson’s disease (PD) is characterized by both motor and non-motor symptoms, including hypokinesia, postural instability, dopaminergic (DA) neurons loss, and α-synuclein (α-syn) accumulation. A growing number of patients show negative responses towards the current therapies. Thus, preventative or disease-modifying treatment agents are worth to further research. In recent years, compounds extracted from natural sources become promising candidates to treat PD. Chlorogenic acid (CGA) is a phenolic compound appearing in coffee, honeysuckle, and eucommia that showed their potential as antioxidants and neuroprotectors. In this study, we investigated the anti-PD activity of CGA by testing its effect on 1-methyl-4-phenyl-1-1,2,3,6-tetrahydropyridine (MPTP) zebrafish model of PD. It was shown that CGA relieved MPTP-induced PD-like symptoms including DA neurons and blood vessel loss, locomotion reduction, and apoptosis events in brain. Moreover, CGA modulated the expression of PD- and autophagy-related genes (α-syn, lc3b, p62, atg5, atg7, and ulk1b), showing its ability to promote the autophagy which was interrupted in the PD pathology. The unblocked effect of CGA on autophagy was further verified in 6-hydroxydopamine (6-OHDA)-modeled SHSY5Y cells. Our findings indicated that CGA might relieve PD by boosting the autophagy in neuronal cells that makes CGA a potential candidate for anti-PD treatment.
Original language | English |
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Article number | 175950 |
Number of pages | 10 |
Journal | European Journal of Pharmacology |
Volume | 956 |
Early online date | 5 Aug 2023 |
DOIs | |
Publication status | Published - 5 Oct 2023 |
Keywords
- Parkinson’s disease
- Chlorogenic acid
- Dopaminergic neurons
- SHSY5Y cells
- 1-Methyl-4-phenyl-1-1,2,3,6-
- tetrahydropyridine
- 6-Hydroxydopamine
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- 2 Finished
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H2020_COLLAB_NEURAM_(CO-ORDINATOR)
Sik, A., Müller, F., Davies, P. & Fossey, J.
1/10/16 → 30/11/22
Project: EU
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Importance of Long-Range Inhibitory Connections in Hippocampal Network Oscillations
Sik, A.
1/10/11 → 30/09/15
Project: Research Councils