Neuroblastoma arginine addiction subverts the anticancer immune response

Carmela De Santo, Francis Mussai

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


High-risk neuroblastoma continues to have a poor prognosis, stimulating the ongoing development of alternative immune-therapy approaches. Despite exciting preclinical results, clinical outcomes have been less clear. Recently we identified that neuroblastoma expresses Arginase II, depleting local and systemic arginine concentrations, and suppression of autologous and engineered T cell immunity.

Original languageEnglish
Article numbere1078967
Number of pages2
Issue number2
Publication statusPublished - Feb 2016


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