Abstract
Objective: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task. Method: Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm. Results: During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group. Conclusion: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.
Original language | English |
---|---|
Pages (from-to) | 295-301 |
Number of pages | 7 |
Journal | Acta Psychiatrica Scandinavica |
Volume | 122 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2010 |
Keywords
- fMRI
- imaging
- motor
- psychosis
- schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health