Nanoparticles of chitosan conjugated to organo-ruthenium complexes

Yanqing Wang, Anaïs Pitto-barry, Abraha Habtemariam, Isolda Romero-canelon, Peter J. Sadler, Nicolas P. E. Barry

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The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.
Original languageEnglish
Pages (from-to)1058-1064
JournalInorganic Chemistry Frontiers
Issue number8
Publication statusPublished - 21 Jun 2016


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