TY - JOUR
T1 - Nanoparticles of chitosan conjugated to organo-ruthenium complexes
AU - Wang, Yanqing
AU - Pitto-barry, Anaïs
AU - Habtemariam, Abraha
AU - Romero-canelon, Isolda
AU - Sadler, Peter J.
AU - Barry, Nicolas P. E.
PY - 2016/6/21
Y1 - 2016/6/21
N2 - The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.
AB - The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.
U2 - 10.1039/C6QI00115G
DO - 10.1039/C6QI00115G
M3 - Article
SN - 2052-1545
VL - 3
SP - 1058
EP - 1064
JO - Inorganic Chemistry Frontiers
JF - Inorganic Chemistry Frontiers
IS - 8
ER -