Nanofocused synchrotron x-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

Carlos Sanchez-Cano; Diego  Gianolio; Isolda Romero-Canelón; Remi Tucoulou; Peter J. Sadler

doi:10.1039/C9CC01675A

Nanofocused synchrotron x-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

Carlos Sanchez-Cano, Diego Gianolio, Isolda Romero-Canelón, Remi Tucoulou, Peter J. Sadler

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Abstract

Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both Os ^II and Os ^III species, which are distributed heterogeneously in different areas of the cells.

Original language	English
Pages (from-to)	7065-7068
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	49
Early online date	31 May 2019
DOIs	https://doi.org/10.1039/C9CC01675A
Publication status	Published - 21 Jun 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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Sanchez-Cano_et_al_Nanofocused_synchrotron_x-ray_absorption_studies_of_the_intracellular_redox_state_of_an_organometallic_complex_in_cancer_cells_Chemical_Communications_2019Final published version, 2.89 MBLicence: Creative Commons: Attribution (CC BY)

https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc01675aLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Nanofocused synchrotron x-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells",

abstract = "Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both Os II and Os III species, which are distributed heterogeneously in different areas of the cells. ",

author = "Carlos Sanchez-Cano and Diego Gianolio and Isolda Romero-Canel{\'o}n and Remi Tucoulou and Sadler, {Peter J.}",

year = "2019",

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doi = "10.1039/C9CC01675A",

language = "English",

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publisher = "Royal Society of Chemistry",

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T1 - Nanofocused synchrotron x-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

AU - Sanchez-Cano, Carlos

AU - Gianolio, Diego

AU - Romero-Canelón, Isolda

AU - Tucoulou, Remi

AU - Sadler, Peter J.

PY - 2019/6/21

Y1 - 2019/6/21

N2 - Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both Os II and Os III species, which are distributed heterogeneously in different areas of the cells.

AB - Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both Os II and Os III species, which are distributed heterogeneously in different areas of the cells.

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U2 - 10.1039/C9CC01675A

DO - 10.1039/C9CC01675A

M3 - Article

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VL - 55

SP - 7065

EP - 7068

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

Nanofocused synchrotron x-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

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