TY - JOUR
T1 - Muscarinic M1 receptor sequence
T2 - preliminary studies on its effects on cognition and expression
AU - Scarr, Elizabeth
AU - Sundram, Suresh
AU - Deljo, Azita
AU - Cowie, Tiffany Francis
AU - Gibbons, Andrew Stuart
AU - Juzva, Susan
AU - Mackinnon, Andrew
AU - Wood, Stephen J
AU - Testa, Renee
AU - Pantelis, Christos
AU - Dean, Brian
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2012
Y1 - 2012
N2 - It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test than those who are heterozygous. We investigated whether CHRM1 sequence is associated with impaired executive function, a common problem in schizophrenia. We sequenced the CHRM1 using peripheral DNA from 97 people with schizophrenia who completed the Wisconsin Card Sorting Test, a verbal fluency test and the National Adult Reading Test. Clinical severity was assessed using the Positive and Negative Syndrome Scale. To determine whether CHRM1 sequence affected receptor expression, we used post-mortem data, from another cohort, to investigate associations between CHRM1 sequence and mRNA levels. On the Wisconsin Card Sorting Test, 267C/C participants with schizophrenia made more perseverative errors (p
AB - It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test than those who are heterozygous. We investigated whether CHRM1 sequence is associated with impaired executive function, a common problem in schizophrenia. We sequenced the CHRM1 using peripheral DNA from 97 people with schizophrenia who completed the Wisconsin Card Sorting Test, a verbal fluency test and the National Adult Reading Test. Clinical severity was assessed using the Positive and Negative Syndrome Scale. To determine whether CHRM1 sequence affected receptor expression, we used post-mortem data, from another cohort, to investigate associations between CHRM1 sequence and mRNA levels. On the Wisconsin Card Sorting Test, 267C/C participants with schizophrenia made more perseverative errors (p
U2 - 10.1016/j.schres.2012.02.011
DO - 10.1016/j.schres.2012.02.011
M3 - Article
C2 - 22391213
VL - 138
SP - 94
EP - 98
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -