Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population

Michella Ghassibe-Sabbagh; Mary Deeb; Angelique K. Salloum; Francis Mouzaya; Marc Haber; Yasser Al-Sarraj; Youssef Chami; Yasmine Akle; Kamal Hirbli; Rita Nemr; Rechdi Ahdab; Daniel E. Platt; Antoine B. Abchee; Hatem El-Shanti; Pierre A. Zalloua

doi:10.1186/1758-5996-6-89

Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population

Michella Ghassibe-Sabbagh, Mary Deeb, Angelique K. Salloum, Francis Mouzaya, Marc Haber, Yasser Al-Sarraj, Youssef Chami, Yasmine Akle, Kamal Hirbli, Rita Nemr, Rechdi Ahdab, Daniel E. Platt, Antoine B. Abchee, Hatem El-Shanti, Pierre A. Zalloua^*

^*Corresponding author for this work

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk factors.

Methods. Participants had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. Clinical and demographic information were obtained from a detailed questionnaire. The relationship between T2DM, its risk factors, and its complications were tested. Comparisons of these risk factors among diabetics, healthy, and coronary artery disease (CAD) patients were performed.

Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). Exercise activity level negatively correlated with the disease (p = 0.002), whereas the prevalence of T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with the affection status. The mean levels of triglycerides and LDL-C were significantly higher in diabetics (1.87; 1.35) compared to individuals with prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 0.0001) were highly associated with T2DM and prediabetes. Reproductive health of women showed a strong correlation between giving birth to a baby with a high weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). Retinopathy and peripheral neuropathy were significantly correlated with diabetes and prediabetes (p < 0.0001).

Conclusions: The present study shows an alarming prevalence of diabetes and prediabetes in the studied subgroups representative of the Lebanese population.

Original language	English
Article number	89
Number of pages	12
Journal	Diabetology and Metabolic Syndrome
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/1758-5996-6-89
Publication status	Published - 21 Aug 2014

Keywords

Coronary artery disease
Hyperlipidemia
Lebanon
Prediabetes
Risk factors
Type 2 diabetes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Ghassibe-Sabbagh, M., Deeb, M., Salloum, A. K., Mouzaya, F., Haber, M., Al-Sarraj, Y., Chami, Y., Akle, Y., Hirbli, K., Nemr, R., Ahdab, R., Platt, D. E., Abchee, A. B., El-Shanti, H., & Zalloua, P. A. (2014). Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population. Diabetology and Metabolic Syndrome, 6(1), Article 89. https://doi.org/10.1186/1758-5996-6-89

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title = "Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population",

abstract = "Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk factors. Methods. Participants had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. Clinical and demographic information were obtained from a detailed questionnaire. The relationship between T2DM, its risk factors, and its complications were tested. Comparisons of these risk factors among diabetics, healthy, and coronary artery disease (CAD) patients were performed. Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). Exercise activity level negatively correlated with the disease (p = 0.002), whereas the prevalence of T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with the affection status. The mean levels of triglycerides and LDL-C were significantly higher in diabetics (1.87; 1.35) compared to individuals with prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 0.0001) were highly associated with T2DM and prediabetes. Reproductive health of women showed a strong correlation between giving birth to a baby with a high weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). Retinopathy and peripheral neuropathy were significantly correlated with diabetes and prediabetes (p < 0.0001). Conclusions: The present study shows an alarming prevalence of diabetes and prediabetes in the studied subgroups representative of the Lebanese population.",

keywords = "Coronary artery disease, Hyperlipidemia, Lebanon, Prediabetes, Risk factors, Type 2 diabetes",

author = "Michella Ghassibe-Sabbagh and Mary Deeb and Salloum, {Angelique K.} and Francis Mouzaya and Marc Haber and Yasser Al-Sarraj and Youssef Chami and Yasmine Akle and Kamal Hirbli and Rita Nemr and Rechdi Ahdab and Platt, {Daniel E.} and Abchee, {Antoine B.} and Hatem El-Shanti and Zalloua, {Pierre A.}",

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language = "English",

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journal = "Diabetology and Metabolic Syndrome",

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Ghassibe-Sabbagh, M, Deeb, M, Salloum, AK, Mouzaya, F, Haber, M, Al-Sarraj, Y, Chami, Y, Akle, Y, Hirbli, K, Nemr, R, Ahdab, R, Platt, DE, Abchee, AB, El-Shanti, H & Zalloua, PA 2014, 'Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population', Diabetology and Metabolic Syndrome, vol. 6, no. 1, 89. https://doi.org/10.1186/1758-5996-6-89

TY - JOUR

T1 - Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population

AU - Ghassibe-Sabbagh, Michella

AU - Deeb, Mary

AU - Salloum, Angelique K.

AU - Mouzaya, Francis

AU - Haber, Marc

AU - Al-Sarraj, Yasser

AU - Chami, Youssef

AU - Akle, Yasmine

AU - Hirbli, Kamal

AU - Nemr, Rita

AU - Ahdab, Rechdi

AU - Platt, Daniel E.

AU - Abchee, Antoine B.

AU - El-Shanti, Hatem

AU - Zalloua, Pierre A.

PY - 2014/8/21

Y1 - 2014/8/21

N2 - Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk factors. Methods. Participants had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. Clinical and demographic information were obtained from a detailed questionnaire. The relationship between T2DM, its risk factors, and its complications were tested. Comparisons of these risk factors among diabetics, healthy, and coronary artery disease (CAD) patients were performed. Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). Exercise activity level negatively correlated with the disease (p = 0.002), whereas the prevalence of T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with the affection status. The mean levels of triglycerides and LDL-C were significantly higher in diabetics (1.87; 1.35) compared to individuals with prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 0.0001) were highly associated with T2DM and prediabetes. Reproductive health of women showed a strong correlation between giving birth to a baby with a high weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). Retinopathy and peripheral neuropathy were significantly correlated with diabetes and prediabetes (p < 0.0001). Conclusions: The present study shows an alarming prevalence of diabetes and prediabetes in the studied subgroups representative of the Lebanese population.

AB - Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk factors. Methods. Participants had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. Clinical and demographic information were obtained from a detailed questionnaire. The relationship between T2DM, its risk factors, and its complications were tested. Comparisons of these risk factors among diabetics, healthy, and coronary artery disease (CAD) patients were performed. Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). Exercise activity level negatively correlated with the disease (p = 0.002), whereas the prevalence of T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with the affection status. The mean levels of triglycerides and LDL-C were significantly higher in diabetics (1.87; 1.35) compared to individuals with prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 0.0001) were highly associated with T2DM and prediabetes. Reproductive health of women showed a strong correlation between giving birth to a baby with a high weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). Retinopathy and peripheral neuropathy were significantly correlated with diabetes and prediabetes (p < 0.0001). Conclusions: The present study shows an alarming prevalence of diabetes and prediabetes in the studied subgroups representative of the Lebanese population.

KW - Coronary artery disease

KW - Hyperlipidemia

KW - Lebanon

KW - Prediabetes

KW - Risk factors

KW - Type 2 diabetes

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DO - 10.1186/1758-5996-6-89

M3 - Article

AN - SCOPUS:84906927524

SN - 1758-5996

VL - 6

JO - Diabetology and Metabolic Syndrome

JF - Diabetology and Metabolic Syndrome

IS - 1

M1 - 89

ER -

Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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