Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy"

M A Bruno; D Fernández-Espejo; R Lehembre; L Tshibanda; A Vanhaudenhuyse; O Gosseries; E Lommers; M Napolitani; Q Noirhomme; M Boly; M Papa; A Owen; P Maquet; S Laureys; A Soddu

doi:10.1016/B978-0-444-53839-0.00021-1

Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy"

M A Bruno, D Fernández-Espejo, R Lehembre, L Tshibanda, A Vanhaudenhuyse, O Gosseries, E Lommers, M Napolitani, Q Noirhomme, M Boly, M Papa, A Owen, P Maquet, S Laureys, A Soddu

Psychology

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.

Original language	English
Pages (from-to)	323-33
Number of pages	11
Journal	Progress in brain research
Volume	193
DOIs	https://doi.org/10.1016/B978-0-444-53839-0.00021-1
Publication status	Published - 2011

Keywords

Adolescent
Brain
Brain Injuries
Consciousness
Consciousness Disorders
Diagnostic Imaging
Diffusion Tensor Imaging
Electroencephalography
Hemispherectomy
Humans
Magnetic Resonance Imaging
Male
Neuroimaging
Neuropsychological Tests
Persistent Vegetative State
Positron-Emission Tomography
Young Adult

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10.1016/B978-0-444-53839-0.00021-1

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Bruno, M. A., Fernández-Espejo, D., Lehembre, R., Tshibanda, L., Vanhaudenhuyse, A., Gosseries, O., Lommers, E., Napolitani, M., Noirhomme, Q., Boly, M., Papa, M., Owen, A., Maquet, P., Laureys, S., & Soddu, A. (2011). Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy". Progress in brain research, 193, 323-33. https://doi.org/10.1016/B978-0-444-53839-0.00021-1

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title = "Multimodal neuroimaging in patients with disorders of consciousness showing {"}functional hemispherectomy{"}",

abstract = "Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in {"}resting state{"} conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a {"}fluctuating{"} minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.",

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author = "Bruno, {M A} and D Fern{\'a}ndez-Espejo and R Lehembre and L Tshibanda and A Vanhaudenhuyse and O Gosseries and E Lommers and M Napolitani and Q Noirhomme and M Boly and M Papa and A Owen and P Maquet and S Laureys and A Soddu",

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Bruno, MA, Fernández-Espejo, D, Lehembre, R, Tshibanda, L, Vanhaudenhuyse, A, Gosseries, O, Lommers, E, Napolitani, M, Noirhomme, Q, Boly, M, Papa, M, Owen, A, Maquet, P, Laureys, S & Soddu, A 2011, 'Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy"', Progress in brain research, vol. 193, pp. 323-33. https://doi.org/10.1016/B978-0-444-53839-0.00021-1

TY - JOUR

T1 - Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy"

AU - Bruno, M A

AU - Fernández-Espejo, D

AU - Lehembre, R

AU - Tshibanda, L

AU - Vanhaudenhuyse, A

AU - Gosseries, O

AU - Lommers, E

AU - Napolitani, M

AU - Noirhomme, Q

AU - Boly, M

AU - Papa, M

AU - Owen, A

AU - Maquet, P

AU - Laureys, S

AU - Soddu, A

PY - 2011

Y1 - 2011

N2 - Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.

AB - Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.

KW - Adolescent

KW - Brain

KW - Brain Injuries

KW - Consciousness

KW - Consciousness Disorders

KW - Diagnostic Imaging

KW - Diffusion Tensor Imaging

KW - Electroencephalography

KW - Hemispherectomy

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Neuroimaging

KW - Neuropsychological Tests

KW - Persistent Vegetative State

KW - Positron-Emission Tomography

KW - Young Adult

U2 - 10.1016/B978-0-444-53839-0.00021-1

DO - 10.1016/B978-0-444-53839-0.00021-1

M3 - Article

C2 - 21854972

SN - 0079-6123

VL - 193

SP - 323

EP - 333

JO - Progress in brain research

JF - Progress in brain research

ER -

Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy"

Abstract

Keywords

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