TY - JOUR
T1 - Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy"
AU - Bruno, M A
AU - Fernández-Espejo, D
AU - Lehembre, R
AU - Tshibanda, L
AU - Vanhaudenhuyse, A
AU - Gosseries, O
AU - Lommers, E
AU - Napolitani, M
AU - Noirhomme, Q
AU - Boly, M
AU - Papa, M
AU - Owen, A
AU - Maquet, P
AU - Laureys, S
AU - Soddu, A
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.
AB - Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.
KW - Adolescent
KW - Brain
KW - Brain Injuries
KW - Consciousness
KW - Consciousness Disorders
KW - Diagnostic Imaging
KW - Diffusion Tensor Imaging
KW - Electroencephalography
KW - Hemispherectomy
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Neuroimaging
KW - Neuropsychological Tests
KW - Persistent Vegetative State
KW - Positron-Emission Tomography
KW - Young Adult
U2 - 10.1016/B978-0-444-53839-0.00021-1
DO - 10.1016/B978-0-444-53839-0.00021-1
M3 - Article
C2 - 21854972
SN - 0079-6123
VL - 193
SP - 323
EP - 333
JO - Progress in brain research
JF - Progress in brain research
ER -