Molecular mechanisms of antibiotic resistance revisited

Elizabeth M Darby; Eleftheria Trampari; Pauline Siasat; Maria Solsona Gaya; Ilyas Alav; Mark A Webber; Jessica M A Blair

doi:10.1038/s41579-022-00820-y

Molecular mechanisms of antibiotic resistance revisited

Elizabeth M Darby, Eleftheria Trampari, Pauline Siasat, Maria Solsona Gaya, Ilyas Alav, Mark A Webber^*, Jessica M A Blair^*

^*Corresponding author for this work

Microbiology and Infection

Research output: Contribution to journal › Review article › peer-review

Abstract

Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.

Original language	English
Pages (from-to)	280–295
Number of pages	16
Journal	Nature Reviews Microbiology
Volume	21
Issue number	5
Early online date	21 Nov 2022
DOIs	https://doi.org/10.1038/s41579-022-00820-y
Publication status	Published - May 2023

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title = "Molecular mechanisms of antibiotic resistance revisited",

abstract = "Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.",

author = "Darby, {Elizabeth M} and Eleftheria Trampari and Pauline Siasat and Gaya, {Maria Solsona} and Ilyas Alav and Webber, {Mark A} and Blair, {Jessica M A}",

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AU - Darby, Elizabeth M

AU - Trampari, Eleftheria

AU - Siasat, Pauline

AU - Gaya, Maria Solsona

AU - Alav, Ilyas

AU - Webber, Mark A

AU - Blair, Jessica M A

PY - 2023/5

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N2 - Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.

AB - Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.

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DO - 10.1038/s41579-022-00820-y

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VL - 21

SP - 280

EP - 295

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 5

ER -

Molecular mechanisms of antibiotic resistance revisited

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