Modified beer-lambert law for blood flow

Wesley B. Baker; Ashwin B. Parthasarathy; David R. Busch; Rickson C. Mesquita; Joel H. Greenberg; A. G. Yodh

doi:10.1117/12.2080185

Modified beer-lambert law for blood flow

Wesley B. Baker, Ashwin B. Parthasarathy, David R. Busch, Rickson C. Mesquita, Joel H. Greenberg, A. G. Yodh

Computer Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

The modified Beer-Lambert law is among the most widely used approaches for analysis of near-infrared spectroscopy (NIRS) reflectance signals for measurements of tissue blood volume and oxygenation. Briefly, the modified Beer-Lambert paradigm is a scheme to derive changes in tissue optical properties based on continuous-wave (CW) diffuse optical intensity measurements. In its simplest form, the scheme relates differential changes in light transmission (in any geometry) to differential changes in tissue absorption. Here we extend this paradigm to the measurement of tissue blood flow by diffuse correlation spectroscopy (DCS). In the new approach, differential changes of the intensity temporal auto-correlation function at a single delay-time are related to differential changes in blood flow. The key theoretical results for measurement of blood flow changes in any tissue geometry are derived, and we demonstrate the new method to monitor cerebral blood flow in a pig under conditions wherein the semi-infinite geometry approximation is fairly good. Specifically, the drug dinitrophenol was injected in the pig to induce a gradual 200% increase in cerebral blood flow, as measured with MRI velocity flow mapping and by DCS. The modified Beer-Lambert law for flow accurately recovered these flow changes using only a single delay-time in the intensity auto-correlation function curve. The scheme offers increased DCS measurement speed of blood flow. Further, the same techniques using the modified Beer-Lambert law to filter out superficial tissue effects in NIRS measurements of deep tissues can be applied to the DCS modified Beer-Lambert law for blood flow monitoring of deep tissues.

Original language	English
Title of host publication	Optical Tomography and Spectroscopy of Tissue XI
Editors	Robert R. Alfano, Eva M. Sevick-Muraca, Bruce J. Tromberg, Arjun G. Yodh
Publisher	SPIE
ISBN (Electronic)	9781628414097
DOIs	https://doi.org/10.1117/12.2080185
Publication status	Published - 2015
Event	Optical Tomography and Spectroscopy of Tissue XI - San Francisco, United States Duration: 9 Feb 2015 → 11 Feb 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9319
ISSN (Print)	1605-7422

Conference

Conference	Optical Tomography and Spectroscopy of Tissue XI
Country/Territory	United States
City	San Francisco
Period	9/02/15 → 11/02/15

Bibliographical note

Publisher Copyright:
© 2015 SPIE.

Keywords

Optical blood flow monitoring
speckle
Spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2080185

Cite this

Baker, W. B., Parthasarathy, A. B., Busch, D. R., Mesquita, R. C., Greenberg, J. H., & Yodh, A. G. (2015). Modified beer-lambert law for blood flow. In R. R. Alfano, E. M. Sevick-Muraca, B. J. Tromberg, & A. G. Yodh (Eds.), Optical Tomography and Spectroscopy of Tissue XI Article 931919 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9319). SPIE. https://doi.org/10.1117/12.2080185

@inproceedings{801d9340bb264176875b7caac32b7c98,

title = "Modified beer-lambert law for blood flow",

abstract = "The modified Beer-Lambert law is among the most widely used approaches for analysis of near-infrared spectroscopy (NIRS) reflectance signals for measurements of tissue blood volume and oxygenation. Briefly, the modified Beer-Lambert paradigm is a scheme to derive changes in tissue optical properties based on continuous-wave (CW) diffuse optical intensity measurements. In its simplest form, the scheme relates differential changes in light transmission (in any geometry) to differential changes in tissue absorption. Here we extend this paradigm to the measurement of tissue blood flow by diffuse correlation spectroscopy (DCS). In the new approach, differential changes of the intensity temporal auto-correlation function at a single delay-time are related to differential changes in blood flow. The key theoretical results for measurement of blood flow changes in any tissue geometry are derived, and we demonstrate the new method to monitor cerebral blood flow in a pig under conditions wherein the semi-infinite geometry approximation is fairly good. Specifically, the drug dinitrophenol was injected in the pig to induce a gradual 200% increase in cerebral blood flow, as measured with MRI velocity flow mapping and by DCS. The modified Beer-Lambert law for flow accurately recovered these flow changes using only a single delay-time in the intensity auto-correlation function curve. The scheme offers increased DCS measurement speed of blood flow. Further, the same techniques using the modified Beer-Lambert law to filter out superficial tissue effects in NIRS measurements of deep tissues can be applied to the DCS modified Beer-Lambert law for blood flow monitoring of deep tissues.",

keywords = "Optical blood flow monitoring, speckle, Spectroscopy",

author = "Baker, {Wesley B.} and Parthasarathy, {Ashwin B.} and Busch, {David R.} and Mesquita, {Rickson C.} and Greenberg, {Joel H.} and Yodh, {A. G.}",

note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Optical Tomography and Spectroscopy of Tissue XI ; Conference date: 09-02-2015 Through 11-02-2015",

year = "2015",

doi = "10.1117/12.2080185",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Alfano, {Robert R.} and Sevick-Muraca, {Eva M.} and Tromberg, {Bruce J.} and Yodh, {Arjun G.}",

booktitle = "Optical Tomography and Spectroscopy of Tissue XI",

}

Baker, WB, Parthasarathy, AB, Busch, DR, Mesquita, RC, Greenberg, JH & Yodh, AG 2015, Modified beer-lambert law for blood flow. in RR Alfano, EM Sevick-Muraca, BJ Tromberg & AG Yodh (eds), Optical Tomography and Spectroscopy of Tissue XI., 931919, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9319, SPIE, Optical Tomography and Spectroscopy of Tissue XI, San Francisco, United States, 9/02/15. https://doi.org/10.1117/12.2080185

Modified beer-lambert law for blood flow. / Baker, Wesley B.; Parthasarathy, Ashwin B.; Busch, David R. et al.
Optical Tomography and Spectroscopy of Tissue XI. ed. / Robert R. Alfano; Eva M. Sevick-Muraca; Bruce J. Tromberg; Arjun G. Yodh. SPIE, 2015. 931919 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9319).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Modified beer-lambert law for blood flow

AU - Baker, Wesley B.

AU - Parthasarathy, Ashwin B.

AU - Busch, David R.

AU - Mesquita, Rickson C.

AU - Greenberg, Joel H.

AU - Yodh, A. G.

PY - 2015

Y1 - 2015

N2 - The modified Beer-Lambert law is among the most widely used approaches for analysis of near-infrared spectroscopy (NIRS) reflectance signals for measurements of tissue blood volume and oxygenation. Briefly, the modified Beer-Lambert paradigm is a scheme to derive changes in tissue optical properties based on continuous-wave (CW) diffuse optical intensity measurements. In its simplest form, the scheme relates differential changes in light transmission (in any geometry) to differential changes in tissue absorption. Here we extend this paradigm to the measurement of tissue blood flow by diffuse correlation spectroscopy (DCS). In the new approach, differential changes of the intensity temporal auto-correlation function at a single delay-time are related to differential changes in blood flow. The key theoretical results for measurement of blood flow changes in any tissue geometry are derived, and we demonstrate the new method to monitor cerebral blood flow in a pig under conditions wherein the semi-infinite geometry approximation is fairly good. Specifically, the drug dinitrophenol was injected in the pig to induce a gradual 200% increase in cerebral blood flow, as measured with MRI velocity flow mapping and by DCS. The modified Beer-Lambert law for flow accurately recovered these flow changes using only a single delay-time in the intensity auto-correlation function curve. The scheme offers increased DCS measurement speed of blood flow. Further, the same techniques using the modified Beer-Lambert law to filter out superficial tissue effects in NIRS measurements of deep tissues can be applied to the DCS modified Beer-Lambert law for blood flow monitoring of deep tissues.

AB - The modified Beer-Lambert law is among the most widely used approaches for analysis of near-infrared spectroscopy (NIRS) reflectance signals for measurements of tissue blood volume and oxygenation. Briefly, the modified Beer-Lambert paradigm is a scheme to derive changes in tissue optical properties based on continuous-wave (CW) diffuse optical intensity measurements. In its simplest form, the scheme relates differential changes in light transmission (in any geometry) to differential changes in tissue absorption. Here we extend this paradigm to the measurement of tissue blood flow by diffuse correlation spectroscopy (DCS). In the new approach, differential changes of the intensity temporal auto-correlation function at a single delay-time are related to differential changes in blood flow. The key theoretical results for measurement of blood flow changes in any tissue geometry are derived, and we demonstrate the new method to monitor cerebral blood flow in a pig under conditions wherein the semi-infinite geometry approximation is fairly good. Specifically, the drug dinitrophenol was injected in the pig to induce a gradual 200% increase in cerebral blood flow, as measured with MRI velocity flow mapping and by DCS. The modified Beer-Lambert law for flow accurately recovered these flow changes using only a single delay-time in the intensity auto-correlation function curve. The scheme offers increased DCS measurement speed of blood flow. Further, the same techniques using the modified Beer-Lambert law to filter out superficial tissue effects in NIRS measurements of deep tissues can be applied to the DCS modified Beer-Lambert law for blood flow monitoring of deep tissues.

KW - Optical blood flow monitoring

KW - speckle

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84928710776&partnerID=8YFLogxK

U2 - 10.1117/12.2080185

DO - 10.1117/12.2080185

M3 - Conference contribution

AN - SCOPUS:84928710776

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Tomography and Spectroscopy of Tissue XI

A2 - Alfano, Robert R.

A2 - Sevick-Muraca, Eva M.

A2 - Tromberg, Bruce J.

A2 - Yodh, Arjun G.

PB - SPIE

T2 - Optical Tomography and Spectroscopy of Tissue XI

Y2 - 9 February 2015 through 11 February 2015

ER -

Modified beer-lambert law for blood flow

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this