Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Simon Jones, S M V Brockbank, K M Clements, N Le Good, D Campbell, S J Read, M R C Needham, P Newham

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

To examine the role of mitogen-activated protein kinase-activated protein kinase 2 (MK2) in mediating the cellular response to pro-inflammatory cytokines in human primary osteoarthritis (OA) chondrocytes.
Original languageEnglish
Pages (from-to)124-31
Number of pages8
JournalOsteoarthritis and Cartilage
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Adenoviridae
  • Peptide Hydrolases
  • Enzyme Activation
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Cartilage, Articular
  • Aged
  • Chondrocytes
  • Interleukin-1beta
  • RNA, Small Interfering
  • Protein-Serine-Threonine Kinases
  • Osteoarthritis, Knee
  • Dinoprostone
  • MAP Kinase Signaling System
  • Phosphorylation
  • Transfection
  • Cells, Cultured
  • Genetic Vectors
  • Middle Aged
  • Male

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