Microbial Primer: Multidrug efflux pumps

Pauline Ann Siasat; Jessica M A Blair

doi:10.1099/mic.0.001370

Microbial Primer: Multidrug efflux pumps

Pauline Ann Siasat, Jessica M A Blair^*

^*Corresponding author for this work

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

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Abstract

Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial compounds within bacteria. These transporters are often overexpressed in clinical isolates, leading to multidrug-resistant phenotypes. Efflux pumps are classified into several families based on their structure and understanding the characteristics of each family is important for the development of novel therapies to restore antibiotic potency.

Original language	English
Article number	001370
Journal	Microbiology
Volume	169
Issue number	10
DOIs	https://doi.org/10.1099/mic.0.001370
Publication status	Published - 3 Oct 2023

Keywords

Humans
Cytoplasm
Periplasm
Cell Membrane
Anti-Bacterial Agents/pharmacology
Membrane Transport Proteins/genetics

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10.1099/mic.0.001370Licence: Creative Commons: Attribution (CC BY)

SiasatPA2023MicrobialFinal published version, 712 KBLicence: Creative Commons: Attribution (CC BY)

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AB - Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial compounds within bacteria. These transporters are often overexpressed in clinical isolates, leading to multidrug-resistant phenotypes. Efflux pumps are classified into several families based on their structure and understanding the characteristics of each family is important for the development of novel therapies to restore antibiotic potency.

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KW - Cytoplasm

KW - Periplasm

KW - Cell Membrane

KW - Anti-Bacterial Agents/pharmacology

KW - Membrane Transport Proteins/genetics

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Microbial Primer: Multidrug efflux pumps

Abstract

Keywords

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