Abstract
A key challenge in chemical biology is to identify small molecule regulators for every single protein. However, protein surfaces are notoriously difficult to recognise with synthetic molecules, often having large flat surfaces that are poorly matched to traditional small molecules. In the surface mimetic approach, a supramolecular scaffold is used to project recognition groups in such a manner as to make multivalent non-covalent contacts over a large area of protein surface. Metal based supramolecular scaffolds offer unique advantages over conventional organic molecules for protein binding, including greater stereochemical and geometrical diversity conferred through the metal centre and the potential for direct assessment of binding properties and even visualisation in cells without recourse to further functionalisation. This feature article will highlight the current state of the art in protein surface recognition using metal complexes as surface mimetics.
Original language | English |
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Pages (from-to) | 9745-9756 |
Number of pages | 12 |
Journal | Chemical Communications |
Volume | 52 |
Issue number | 63 |
DOIs | |
Publication status | Published - 2016 |
Bibliographical note
Funding Information:This work was supported by the Engineering and Physical Sciences Research Council [EP/L504993/1, EP/F039069 and EP/F038712] and by the European Research Council [ERC-StG-240324]
Publisher Copyright:
© The 2016 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry