Projects per year
Abstract
Histopathologically well-characterized fish liver was analyzed by 800 MHz (1)H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were analyzed by multivariate statistics and metabolic correlation networks, and results revealed elevated anaerobic metabolism and reduced choline metabolism in tumor tissue. Significant negative correlations were observed between alanine-acetate ( p = 3.0 x 10 (-5)) and between proline-acetate ( p = 0.003) in tumors only, suggesting alanine and proline are utilized as alternative energy sources in flatfish liver tumors.
Original language | English |
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Pages (from-to) | 5277-5285 |
Number of pages | 9 |
Journal | Journal of Proteome Research |
Volume | 7 |
DOIs | |
Publication status | Published - 11 Nov 2008 |
Keywords
- Environment
- hepatocellular adenoma
- fingerprinting
- false discovery rate
- dab flatfish
- profiling
- metabolic networks
- cancer
- FDR
- succinate
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Dive into the research topics of 'Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks.'. Together they form a unique fingerprint.Projects
- 1 Finished
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Fellowship: Dr M.R. Viant: Development of a Predictive Biomarker Model for the Marine and Estuarine Environments using state-of-the-art NMR-based Metabonomics and Bioinformatic Techniques
Viant, M. (Principal Investigator)
Natural Environment Research Council
1/11/03 → 6/01/09
Project: Research Councils