Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks.

Andrew Southam; John Easton; GD Stentiford; Christian Ludwig; Theodoros Arvanitis; Mark Viant

doi:10.1021/pr800353t

Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks.

Andrew Southam, John Easton, GD Stentiford, Christian Ludwig, Theodoros Arvanitis, Mark Viant

Research output: Contribution to journal › Article

50 Citations (Scopus)

Abstract

Histopathologically well-characterized fish liver was analyzed by 800 MHz (1)H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were analyzed by multivariate statistics and metabolic correlation networks, and results revealed elevated anaerobic metabolism and reduced choline metabolism in tumor tissue. Significant negative correlations were observed between alanine-acetate ( p = 3.0 x 10 (-5)) and between proline-acetate ( p = 0.003) in tumors only, suggesting alanine and proline are utilized as alternative energy sources in flatfish liver tumors.

Original language	English
Pages (from-to)	5277-5285
Number of pages	9
Journal	Journal of Proteome Research
Volume	7
DOIs	https://doi.org/10.1021/pr800353t
Publication status	Published - 11 Nov 2008

Keywords

Environment
hepatocellular adenoma
fingerprinting
false discovery rate
dab flatfish
profiling
metabolic networks
cancer
FDR
succinate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/pr800353t

Fellowship: Dr M.R. Viant: Development of a Predictive Biomarker Model for the Marine and Estuarine Environments using state-of-the-art NMR-based Metabonomics and Bioinformatic Techniques
Viant, M.
Natural Environment Research Council
1/11/03 → 6/01/09
Project: Research Councils

Cite this

@article{9face66321644bcf8146e2f3923b4eab,

title = "Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks.",

abstract = "Histopathologically well-characterized fish liver was analyzed by 800 MHz (1)H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were analyzed by multivariate statistics and metabolic correlation networks, and results revealed elevated anaerobic metabolism and reduced choline metabolism in tumor tissue. Significant negative correlations were observed between alanine-acetate ( p = 3.0 x 10 (-5)) and between proline-acetate ( p = 0.003) in tumors only, suggesting alanine and proline are utilized as alternative energy sources in flatfish liver tumors.",

keywords = "Environment, hepatocellular adenoma, fingerprinting, false discovery rate, dab flatfish, profiling, metabolic networks, cancer, FDR, succinate",

author = "Andrew Southam and John Easton and GD Stentiford and Christian Ludwig and Theodoros Arvanitis and Mark Viant",

year = "2008",

month = nov,

day = "11",

doi = "10.1021/pr800353t",

language = "English",

volume = "7",

pages = "5277--5285",

journal = "Journal of Proteome Research",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks.

AU - Southam, Andrew

AU - Easton, John

AU - Stentiford, GD

AU - Ludwig, Christian

AU - Arvanitis, Theodoros

AU - Viant, Mark

PY - 2008/11/11

Y1 - 2008/11/11

N2 - Histopathologically well-characterized fish liver was analyzed by 800 MHz (1)H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were analyzed by multivariate statistics and metabolic correlation networks, and results revealed elevated anaerobic metabolism and reduced choline metabolism in tumor tissue. Significant negative correlations were observed between alanine-acetate ( p = 3.0 x 10 (-5)) and between proline-acetate ( p = 0.003) in tumors only, suggesting alanine and proline are utilized as alternative energy sources in flatfish liver tumors.

AB - Histopathologically well-characterized fish liver was analyzed by 800 MHz (1)H NMR metabolomics to identify metabolic changes between healthy and tumor tissue. Data were analyzed by multivariate statistics and metabolic correlation networks, and results revealed elevated anaerobic metabolism and reduced choline metabolism in tumor tissue. Significant negative correlations were observed between alanine-acetate ( p = 3.0 x 10 (-5)) and between proline-acetate ( p = 0.003) in tumors only, suggesting alanine and proline are utilized as alternative energy sources in flatfish liver tumors.

KW - Environment

KW - hepatocellular adenoma

KW - fingerprinting

KW - false discovery rate

KW - dab flatfish

KW - profiling

KW - metabolic networks

KW - cancer

KW - FDR

KW - succinate

U2 - 10.1021/pr800353t

DO - 10.1021/pr800353t

M3 - Article

C2 - 18998726

VL - 7

SP - 5277

EP - 5285

JO - Journal of Proteome Research

JF - Journal of Proteome Research

ER -

Metabolic Changes in Flatfish Hepatic Tumours Revealed by NMR-Based Metabolomics and Metabolic Correlation Networks.

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Projects

Fellowship: Dr M.R. Viant: Development of a Predictive Biomarker Model for the Marine and Estuarine Environments using state-of-the-art NMR-based Metabonomics and Bioinformatic Techniques

Cite this