Mesenchymal stem cells as endogenous regulators of inflammation

Hafsa Munir, Lewis S.C. Ward, Helen M. McGettrick*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Citations (Scopus)


This chapter discusses the regulatory role of endogenous mesenchymal stem cells (MSC) during an inflammatory response. MSC are a heterogeneous population of multipotent cells that normally contribute towards tissue maintenance and repair but have garnered significant scientific interest for their potent immunomodulatory potential. It is through these physicochemical interactions that MSC are able to exert an anti-inflammatory response on neighbouring stromal and haematopoietic cells. However, the impact of the chronic inflammatory environment on MSC function remains to be determined. Understanding the relationship of MSC between resolution of inflammation and autoimmunity will both offer new insights in the use of MSC as a therapeutic, and also their involvement in the pathogenesis of inflammatory disorders.

Original languageEnglish
Title of host publicationStromal Immunology
Number of pages26
ISBN (Electronic)9783319781273
ISBN (Print)9783319781259
Publication statusPublished - 29 Aug 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Endothelial cells
  • Lymphocytes
  • Mesenchymal stem cells
  • Neutrophils

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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