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Abstract
Down syndrome cell adhesion molecule (Dscam) gene encodes a cell adhesion molecule required for neuronal wiring. A remarkable feature of arthropod Dscam is massive alternative splicing generating thousands of different isoforms from three variable clusters of alternative exons. Dscam expression and diversity arising from alternative splicing have been studied during development, but whether they exert functions in adult brains has not been determined. Here, using honey bees, we find that Dscam expression is critically linked to memory retention as reducing expression by RNAi enhances memory after reward learning in adult worker honey bees. Moreover, alternative splicing of Dscam is altered in all three variable clusters after learning. Since identical Dscam isoforms engage in homophilic interactions, these results suggest a mechanism to alter inclusion of variable exons during memory consolidation to modify neuronal connections for memory retention.
Original language | English |
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Article number | 1322808 |
Number of pages | 11 |
Journal | Frontiers in Molecular Neuroscience |
Volume | 16 |
DOIs | |
Publication status | Published - 9 Jan 2024 |
Bibliographical note
Funding:The author(s) declare financial support was received for the research, authorship, and/or publication of this article. For this work we acknowledge funding from the Sukran Sinan Fund, the Genetics Society, the Biochemical Society, MRC DTP, and BBSRC (BB/T003936/1). J-MD acknowledges funding from the CNRS and Université Paul Sabatier.
Keywords
- Dscam
- alternative splicing
- learning and memory
- honey bee
- RNA interference (gene silencing)
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Drosophila Down Syndrome Cell Adhesion Module: A paradigm for revealing hidden splicing codes
Arnold, R. (Co-Investigator) & Soller, M. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/03/21 → 30/11/25
Project: Research Councils