TY - JOUR
T1 - Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
AU - Sánchez-Tena, Susana
AU - Reyes-Zurita, Fernando J
AU - Díaz-Moralli, Santiago
AU - Vinardell, Maria Pilar
AU - Reed, Michelle
AU - García-García, Francisco
AU - Dopazo, Joaquín
AU - Lupiáñez, José A
AU - Günther, Ulrich
AU - Cascante, Marta
PY - 2013
Y1 - 2013
N2 - Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P
AB - Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P
KW - Animals
KW - Cell Transformation, Neoplastic
KW - Dietary Supplements
KW - Gene Expression Profiling
KW - Genes, APC
KW - Intestinal Polyps
KW - Male
KW - Mice
KW - Mice, Inbred Strains
KW - Microarray Analysis
KW - Real-Time Polymerase Chain Reaction
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Triterpenes
U2 - 10.1371/journal.pone.0059392
DO - 10.1371/journal.pone.0059392
M3 - Article
C2 - 23527181
SN - 1932-6203
VL - 8
SP - e59392
JO - PLoS ONE
JF - PLoS ONE
IS - 3
ER -
