Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming

Susana Sánchez-Tena, Fernando J Reyes-Zurita, Santiago Díaz-Moralli, Maria Pilar Vinardell, Michelle Reed, Francisco García-García, Joaquín Dopazo, José A Lupiáñez, Ulrich Günther, Marta Cascante

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P
Original languageEnglish
Pages (from-to)e59392
JournalPLoS ONE
Volume8
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Animals
  • Cell Transformation, Neoplastic
  • Dietary Supplements
  • Gene Expression Profiling
  • Genes, APC
  • Intestinal Polyps
  • Male
  • Mice
  • Mice, Inbred Strains
  • Microarray Analysis
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Triterpenes

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