Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

ISARIC4C Investigators; Samreen Ijaz; Steve Dicks; Keerthana Jegatheesan; Eleanor Parker; Ksenia Katsanovskaja; Elen Vink; Justin Shute; Myra O. McClure; J. Shute; Joshua Hope; Nicola Cook; Peter Cherepanov; Lance Turtle; William A Paxton; Georgios Pollakis; Antonia Ho; Peter J.M. Openshaw; J Kenneth  Baillie; Malcolm G. Semple; Richard S. Tedder

doi:10.1016/j.jinf.2022.05.033

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

ISARIC4C Investigators, Samreen Ijaz^*, Steve Dicks, Keerthana Jegatheesan, Eleanor Parker, Ksenia Katsanovskaja, Elen Vink, Justin Shute, Myra O. McClure, J. Shute, Joshua Hope, Nicola Cook, Peter Cherepanov, Lance Turtle, William A Paxton, Georgios Pollakis, Antonia Ho, Peter J.M. Openshaw, J Kenneth Baillie, Malcolm G. SempleRichard S. Tedder

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	152-160
Number of pages	9
Journal	Journal of Infection
Volume	85
Issue number	2
Early online date	3 Jun 2022
DOIs	https://doi.org/10.1016/j.jinf.2022.05.033
Publication status	Published - Aug 2022

Bibliographical note

Funding:
This work is supported by grants from: the National Institute for Health Research (NIHR) [award COsingle bondCIN-01], the Medical Research Council [grant MC_PC_19059] and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with UK Health Security Agency (UKHSA), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford [award 200907], NIHR HPRU in Respiratory Infections at Imperial College London with UKHSA [award 200927], NIHR Biomedical Research Centre at Imperial College London [IS-BRC-1215-20013], and NIHR Clinical Research Network for providing infrastructure support for this research. The views expressed are those of the authors and not necessarily those of the NIHR, MRC or UKHSA.

Funding was also available from UKRI CV220-11: Serological detection of past SARS-CoV-2 infection by non-invasive sampling for field epidemiology and quantitative antibody detection; held at Imperial College London.

Work in PC's laboratory was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001061), the Wellcome Trust (FC001061), and the UK Medical Research Council (FC001061).

The funder had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication

Study registration ISRCTN66726260

The ISARIC WHO CCP-UK study was registered at https://www.isrctn.com/ISRCTN66726260 and designated an Urgent Public Health Research Study by NIHR.

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Cite this

ISARIC4C Investigators, Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., Shute, J., McClure, M. O., Shute, J., Hope, J., Cook, N., Cherepanov, P., Turtle, L., Paxton, W. A., Pollakis, G., Ho, A., Openshaw, P. J. M., Baillie, J. K., ... Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. Journal of Infection, 85(2), 152-160. https://doi.org/10.1016/j.jinf.2022.05.033

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title = "Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients",

author = "{ISARIC4C Investigators} and Samreen Ijaz and Steve Dicks and Keerthana Jegatheesan and Eleanor Parker and Ksenia Katsanovskaja and Elen Vink and Justin Shute and McClure, {Myra O.} and J. Shute and Joshua Hope and Nicola Cook and Peter Cherepanov and Lance Turtle and Paxton, {William A} and Georgios Pollakis and Antonia Ho and Openshaw, {Peter J.M.} and Baillie, {J Kenneth} and Semple, {Malcolm G.} and Tedder, {Richard S.} and Christopher Green",

note = "Funding: This work is supported by grants from: the National Institute for Health Research (NIHR) [award COsingle bondCIN-01], the Medical Research Council [grant MC_PC_19059] and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with UK Health Security Agency (UKHSA), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford [award 200907], NIHR HPRU in Respiratory Infections at Imperial College London with UKHSA [award 200927], NIHR Biomedical Research Centre at Imperial College London [IS-BRC-1215-20013], and NIHR Clinical Research Network for providing infrastructure support for this research. The views expressed are those of the authors and not necessarily those of the NIHR, MRC or UKHSA. Funding was also available from UKRI CV220-11: Serological detection of past SARS-CoV-2 infection by non-invasive sampling for field epidemiology and quantitative antibody detection; held at Imperial College London. Work in PC's laboratory was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001061), the Wellcome Trust (FC001061), and the UK Medical Research Council (FC001061). The funder had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication Study registration ISRCTN66726260 The ISARIC WHO CCP-UK study was registered at https://www.isrctn.com/ISRCTN66726260 and designated an Urgent Public Health Research Study by NIHR.",

year = "2022",

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ISARIC4C Investigators, Ijaz, S, Dicks, S, Jegatheesan, K, Parker, E, Katsanovskaja, K, Vink, E, Shute, J, McClure, MO, Shute, J, Hope, J, Cook, N, Cherepanov, P, Turtle, L, Paxton, WA, Pollakis, G, Ho, A, Openshaw, PJM, Baillie, JK, Semple, MG & Tedder, RS 2022, 'Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients', Journal of Infection, vol. 85, no. 2, pp. 152-160. https://doi.org/10.1016/j.jinf.2022.05.033

TY - JOUR

T1 - Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid

T2 - Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

AU - ISARIC4C Investigators

AU - Ijaz, Samreen

AU - Dicks, Steve

AU - Jegatheesan, Keerthana

AU - Parker, Eleanor

AU - Katsanovskaja, Ksenia

AU - Vink, Elen

AU - Shute, Justin

AU - McClure, Myra O.

AU - Shute, J.

AU - Hope, Joshua

AU - Cook, Nicola

AU - Cherepanov, Peter

AU - Turtle, Lance

AU - Paxton, William A

AU - Pollakis, Georgios

AU - Ho, Antonia

AU - Openshaw, Peter J.M.

AU - Baillie, J Kenneth

AU - Semple, Malcolm G.

AU - Tedder, Richard S.

AU - Green, Christopher

N1 - Funding: This work is supported by grants from: the National Institute for Health Research (NIHR) [award COsingle bondCIN-01], the Medical Research Council [grant MC_PC_19059] and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with UK Health Security Agency (UKHSA), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford [award 200907], NIHR HPRU in Respiratory Infections at Imperial College London with UKHSA [award 200927], NIHR Biomedical Research Centre at Imperial College London [IS-BRC-1215-20013], and NIHR Clinical Research Network for providing infrastructure support for this research. The views expressed are those of the authors and not necessarily those of the NIHR, MRC or UKHSA. Funding was also available from UKRI CV220-11: Serological detection of past SARS-CoV-2 infection by non-invasive sampling for field epidemiology and quantitative antibody detection; held at Imperial College London. Work in PC's laboratory was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001061), the Wellcome Trust (FC001061), and the UK Medical Research Council (FC001061). The funder had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication Study registration ISRCTN66726260 The ISARIC WHO CCP-UK study was registered at https://www.isrctn.com/ISRCTN66726260 and designated an Urgent Public Health Research Study by NIHR.

PY - 2022/8

Y1 - 2022/8

U2 - 10.1016/j.jinf.2022.05.033

DO - 10.1016/j.jinf.2022.05.033

M3 - Article

SN - 0163-4453

VL - 85

SP - 152

EP - 160

JO - Journal of Infection

JF - Journal of Infection

IS - 2

ER -