Abstract
Objective. In the light of previous reports of an association between malignancy and renal vasculitis, we aimed to investigate the association of malignancy in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, either Wegener's granulomatosis (WG) or microscopic polyangiitis (MPA), and compare it with the general population and disease control groups comprising patients with systemic lupus erythematosus (SLE) or Henoch-Schonlein purpura (HSP).
Methods. A retrospective review of 200 consecutive patients with WG or MPA was performed. Malignancies preceding or concurrent with vasculitis were recorded and the incidence of malignancy was compared with those in a population of 129 patients with HSP, 333 patients with SLE and a normal population in the West Midlands of the UK.
Results. Twenty patients had a diagnosis of malignancy, 14 had MPA and six had WG. Patients with ANCA-associated vasculitis had an increased risk of malignancy compared with HSP patients, of whom six patients had malignancy (relative risk 0.85, confidence interval 0.69-1.05; P = 0.034), or SLE patients, of whom five patients had malignancy (relative risk 0.31, 95% confidence interval 0.14-0.7; P
Original language | English |
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Pages (from-to) | 1532-5 |
Number of pages | 4 |
Journal | Rheumatology |
Volume | 43 |
Issue number | 12 |
Early online date | 17 Aug 2004 |
DOIs | |
Publication status | Published - Dec 2004 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Antineutrophil Cytoplasmic
- Autoimmune Diseases
- Female
- Glomerulonephritis
- Humans
- Lupus Erythematosus, Systemic
- Male
- Middle Aged
- Neoplasms
- Purpura, Schoenlein-Henoch
- Retrospective Studies
- Risk Assessment
- Vasculitis
- Wegener Granulomatosis