Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1

Rebecca Newman, Helena Ahlfors, Alexander Saveliev, Alison Galloway, Daniel J Hodson, Robert Williams, Gurdyal S Besra, Charlotte N Cook, Adam F Cunningham, Sarah E Bell, Martin Turner

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
297 Downloads (Pure)

Abstract

RNA-binding proteins of the ZFP36 family are best known for inhibiting the expression of cytokines through binding to AU-rich elements in the 3' untranslated region and promoting mRNA decay. Here we identified an indispensable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 and IRF8, which are known to enforce the follicular B cell phenotype. These mechanisms emphasize the importance of integrating transcriptional and post-transcriptional processes by RNA-binding proteins for maintaining cellular identity among closely related cell types.

Original languageEnglish
Pages (from-to)683–693
JournalNature Immunology
Volume18
Early online date10 Apr 2017
DOIs
Publication statusPublished - Jun 2017

Keywords

  • B cells
  • Immunology
  • Lymphocytes

Fingerprint

Dive into the research topics of 'Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1'. Together they form a unique fingerprint.

Cite this