TY - JOUR
T1 - Ly49H(+) NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection
AU - Bekiaris, Vasileios
AU - Timoshenko, Olga
AU - Hou, Tiezheng
AU - Toellner, Kai-Michael
AU - Shakib, S
AU - Gaspal, Fabrina
AU - McConnell, Fiona
AU - Parnell, SM
AU - Withers, David
AU - Buckley, Christopher
AU - Sweet, Clive
AU - Yokoyama, WM
AU - Anderson, Graham
AU - Lane, Peter
PY - 2008/1/1
Y1 - 2008/1/1
N2 - In this study, we show that in the absence of a protective NK cell response, murine CMV causes destruction of splenic white and red pulp pulp areas in the first few days of infection. Destruction of T zone stroma is associated with almost complete loss of dendritic cells and T cells. We provide evidence that the virus replicates in red and white pulp stroma in vivo and in vitro. Control of white pulp viral replication is associated with migration of murine CMV-specific activated NK cells to white pulp areas, where they associate directly with podoplanin-expressing T zone stromal cells. Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might breakdown in immunocompromised patients.
AB - In this study, we show that in the absence of a protective NK cell response, murine CMV causes destruction of splenic white and red pulp pulp areas in the first few days of infection. Destruction of T zone stroma is associated with almost complete loss of dendritic cells and T cells. We provide evidence that the virus replicates in red and white pulp stroma in vivo and in vitro. Control of white pulp viral replication is associated with migration of murine CMV-specific activated NK cells to white pulp areas, where they associate directly with podoplanin-expressing T zone stromal cells. Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might breakdown in immunocompromised patients.
U2 - 10.4049/jimmunol.180.10.6768
DO - 10.4049/jimmunol.180.10.6768
M3 - Article
C2 - 18453597
SN - 0022-1767
VL - 180
SP - 6768
EP - 6776
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -