Low-frequency alternating current stimulation rhythmically suppresses gamma-band oscillations and impairs perceptual performance

Jim D Herring, Sophie Esterer, Tom R Marshall, Ole Jensen, Til O Bergmann

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Low frequency oscillations such as alpha (8-12 Hz) are hypothesized to rhythmically gate sensory processing, reflected by 40-100 Hz gamma band activity, via the mechanism of pulsed inhibition. We applied transcranial alternating current stimulation (TACS) at individual alpha frequency (IAF) and flanking frequencies (IAF-4 Hz, IAF+4 Hz) to the occipital cortex of healthy human volunteers during concurrent magnetoencephalography (MEG), while participants performed a visual detection task inducing strong gamma-band responses. Occipital (but not retinal) TACS phasically suppressed stimulus-induced gamma oscillations in the visual cortex and impaired target detection, with stronger phase-to-amplitude coupling predicting behavioral impairments. Retinal control TACS ruled out retino-thalamo-cortical entrainment resulting from (subthreshold) retinal stimulation. All TACS frequencies tested were effective, suggesting that visual gamma-band responses can be modulated by a range of low frequency oscillations. We propose that TACS-induced membrane potential modulations mimic the rhythmic change in cortical excitability by which spontaneous low frequency oscillations may eventually exert their impact when gating sensory processing via pulsed inhibition.

Original languageEnglish
Pages (from-to)440-449
Number of pages10
JournalNeuroImage
Volume184
Early online date19 Sep 2018
DOIs
Publication statusPublished - 1 Jan 2019

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