Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats

Simon P. Wells; Antonia J.A. Raaijmakers; Claire L. Curl; Christopher O’Shea; Sarah Hayes; Kimberley M. Mellor; Jonathan M. Kalman; Paulus Kirchhof; Davor Pavlovic; Lea M.D. Delbridge; James R. Bell

doi:10.1085/jgp.202213296

Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats

Simon P. Wells, Antonia J.A. Raaijmakers, Claire L. Curl, Christopher O’Shea, Sarah Hayes, Kimberley M. Mellor, Jonathan M. Kalman, Paulus Kirchhof, Davor Pavlovic, Lea M.D. Delbridge^*, James R. Bell^*

^*Corresponding author for this work

Cardiovascular Sciences

Research output: Contribution to journal › Letter › peer-review

Original language	English
Article number	e202213296
Number of pages	10
Journal	Journal of General Physiology
Volume	155
Issue number	11
Early online date	3 Oct 2023
DOIs	https://doi.org/10.1085/jgp.202213296
Publication status	Published - 6 Nov 2023

Bibliographical note

Acknowledgments:
Jeanne M. Nerbonne served as editor.

MATLAB script for the generation of activation maps and conduction velocity analysis was kindly provided by Professor Cesare Terracciano, Imperial College London (London, UK), and is gratefully acknowledged. Technical support was provided by the Melbourne Histology Platform.

This research was supported by the National Health and Medical Research Council (grants #1099352 and #1125453; to L.M.D. Delbridge and J.R. Bell) and the Australian Research Council (grant #DP160102404; to L.M.D. Delbridge). D. Pavlovic is supported by the British Heart Foundation (PG/17/55/33087; RG/17/15/33106; FS/19/12/34204; FS/19/16/34169). C. O’Shea is supported by a Sir Henry Wellcome Fellowship, Wellcome Trust, 221650/Z/20/Z.

Author contributions: S.P. Wells, D. Pavlovic, L.M.D. Delbridge, and J.R. Bell designed the research; S.P. Wells, A.J.A. Raaijmakers, S. Hayes, and J.R. Bell performed experiments; S.P. Wells, A.J.A. Raaijmakers, C.L. Curl, C. O’Shea, S. Hayes, and J.R. Bell analyzed data; and S.P. Wells, K.M. Mellor, J.M. Kalman, L.M.D. Delbridge, and J.R. Bell wrote the paper. All authors approved the final version of the manuscript.

Disclosures: J.M. Kalman reported grants from Medtronic Inc., Biosense Webster, and Zoll outside the submitted work; and Practitioner Fellowship, National Health and Medical Research Council of Australia. P. Kirchhof reported grants from DZHK, BHF, and EU during the conduct of the study, and grants from several companies active in atrial fibrillation outside the submitted work; in addition, P. Kirchhof had a patent to two patents owned by UKE granted issued. No other disclosures were reported.

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1 Active
3 Finished

Development of novel computational approaches for human cardiac mapping data - Improving understanding and treatment of atrialfibrillation
O'Shea, C.
THE WELLCOME TRUST
1/05/21 → 30/04/25
Project: Research
Investigating regulatory pathways for intracellular sodium in the atria
Pavlovic, D. & Thomas, S.
British Heart Foundation
1/10/19 → 30/04/23
Project: Research
Scarred by kidney disease: FGF23 as a key mediator of cardiac fibrosis in patients with chronic kidney disease
Weston, C., Pavlovic, D., McGettrick, H. & Gough, R.
British Heart Foundation
1/08/19 → 28/02/23
Project: Research
Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy
Arlt, W., Pavlovic, D., Taylor, A., Kotecha, D. & Kirchhof, P.
British Heart Foundation
1/06/18 → 30/05/21
Project: Research

Cite this

Wells, S. P., Raaijmakers, A. J. A., Curl, C. L., O’Shea, C., Hayes, S., Mellor, K. M., Kalman, J. M., Kirchhof, P., Pavlovic, D., Delbridge, L. M. D., & Bell, J. R. (2023). Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats. Journal of General Physiology, 155(11), Article e202213296. https://doi.org/10.1085/jgp.202213296

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title = "Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats",

author = "Wells, {Simon P.} and Raaijmakers, {Antonia J.A.} and Curl, {Claire L.} and Christopher O{\textquoteright}Shea and Sarah Hayes and Mellor, {Kimberley M.} and Kalman, {Jonathan M.} and Paulus Kirchhof and Davor Pavlovic and Delbridge, {Lea M.D.} and Bell, {James R.}",

note = "Acknowledgments: Jeanne M. Nerbonne served as editor. MATLAB script for the generation of activation maps and conduction velocity analysis was kindly provided by Professor Cesare Terracciano, Imperial College London (London, UK), and is gratefully acknowledged. Technical support was provided by the Melbourne Histology Platform. This research was supported by the National Health and Medical Research Council (grants #1099352 and #1125453; to L.M.D. Delbridge and J.R. Bell) and the Australian Research Council (grant #DP160102404; to L.M.D. Delbridge). D. Pavlovic is supported by the British Heart Foundation (PG/17/55/33087; RG/17/15/33106; FS/19/12/34204; FS/19/16/34169). C. O{\textquoteright}Shea is supported by a Sir Henry Wellcome Fellowship, Wellcome Trust, 221650/Z/20/Z. Author contributions: S.P. Wells, D. Pavlovic, L.M.D. Delbridge, and J.R. Bell designed the research; S.P. Wells, A.J.A. Raaijmakers, S. Hayes, and J.R. Bell performed experiments; S.P. Wells, A.J.A. Raaijmakers, C.L. Curl, C. O{\textquoteright}Shea, S. Hayes, and J.R. Bell analyzed data; and S.P. Wells, K.M. Mellor, J.M. Kalman, L.M.D. Delbridge, and J.R. Bell wrote the paper. All authors approved the final version of the manuscript. Disclosures: J.M. Kalman reported grants from Medtronic Inc., Biosense Webster, and Zoll outside the submitted work; and Practitioner Fellowship, National Health and Medical Research Council of Australia. P. Kirchhof reported grants from DZHK, BHF, and EU during the conduct of the study, and grants from several companies active in atrial fibrillation outside the submitted work; in addition, P. Kirchhof had a patent to two patents owned by UKE granted issued. No other disclosures were reported. ",

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doi = "10.1085/jgp.202213296",

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T1 - Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats

AU - Wells, Simon P.

AU - Raaijmakers, Antonia J.A.

AU - Curl, Claire L.

AU - O’Shea, Christopher

AU - Hayes, Sarah

AU - Mellor, Kimberley M.

AU - Kalman, Jonathan M.

AU - Kirchhof, Paulus

AU - Pavlovic, Davor

AU - Delbridge, Lea M.D.

AU - Bell, James R.

N1 - Acknowledgments: Jeanne M. Nerbonne served as editor. MATLAB script for the generation of activation maps and conduction velocity analysis was kindly provided by Professor Cesare Terracciano, Imperial College London (London, UK), and is gratefully acknowledged. Technical support was provided by the Melbourne Histology Platform. This research was supported by the National Health and Medical Research Council (grants #1099352 and #1125453; to L.M.D. Delbridge and J.R. Bell) and the Australian Research Council (grant #DP160102404; to L.M.D. Delbridge). D. Pavlovic is supported by the British Heart Foundation (PG/17/55/33087; RG/17/15/33106; FS/19/12/34204; FS/19/16/34169). C. O’Shea is supported by a Sir Henry Wellcome Fellowship, Wellcome Trust, 221650/Z/20/Z. Author contributions: S.P. Wells, D. Pavlovic, L.M.D. Delbridge, and J.R. Bell designed the research; S.P. Wells, A.J.A. Raaijmakers, S. Hayes, and J.R. Bell performed experiments; S.P. Wells, A.J.A. Raaijmakers, C.L. Curl, C. O’Shea, S. Hayes, and J.R. Bell analyzed data; and S.P. Wells, K.M. Mellor, J.M. Kalman, L.M.D. Delbridge, and J.R. Bell wrote the paper. All authors approved the final version of the manuscript. Disclosures: J.M. Kalman reported grants from Medtronic Inc., Biosense Webster, and Zoll outside the submitted work; and Practitioner Fellowship, National Health and Medical Research Council of Australia. P. Kirchhof reported grants from DZHK, BHF, and EU during the conduct of the study, and grants from several companies active in atrial fibrillation outside the submitted work; in addition, P. Kirchhof had a patent to two patents owned by UKE granted issued. No other disclosures were reported.

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DO - 10.1085/jgp.202213296

M3 - Letter

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JO - Journal of General Physiology

JF - Journal of General Physiology

IS - 11

M1 - e202213296

ER -

Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats

Bibliographical note

Access to Document

Embargoed Document

Projects

Development of novel computational approaches for human cardiac mapping data - Improving understanding and treatment of atrialfibrillation

Investigating regulatory pathways for intracellular sodium in the atria

Scarred by kidney disease: FGF23 as a key mediator of cardiac fibrosis in patients with chronic kidney disease

Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy

Cite this