TY - JOUR
T1 - Leg glucose and protein metabolism during an acute bout of resistance exercise in humans
AU - Durham, WJ
AU - Miller, SL
AU - Yeckel, CW
AU - Chinkes, DL
AU - Tipton, Kevin
AU - Rasmussen, BB
AU - Wolfe, RR
PY - 2004/5/14
Y1 - 2004/5/14
N2 - The present study investigated the responses of leg glucose and protein metabolism during an acute bout of resistance exercise. Seven subjects (5 men, 2 women) were studied at rest and during a strenuous lower body resistance exercise regimen consisting of approximately 8 sets of 10 repetitions of leg press at approximately 75% 1 repetition maximum and 8 sets of 8 repetitions of knee extensions at approximately 80% 1 repetition maximum. L-[ring-2H5]phenylalanine was infused throughout the study for measurement of phenylalanine rates of appearance, disappearance, protein synthesis, and protein breakdown across the leg. Femoral arterial and venous blood samples were collected at rest and during exercise for determination of leg blood flow, concentrations of glucose, lactate, alanine, glutamine, glutamate, leucine, and phenylalanine, and phenylalanine enrichments. Muscle biopsies were obtained at rest and immediately after exercise. Leg blood flow was nearly three times (P
AB - The present study investigated the responses of leg glucose and protein metabolism during an acute bout of resistance exercise. Seven subjects (5 men, 2 women) were studied at rest and during a strenuous lower body resistance exercise regimen consisting of approximately 8 sets of 10 repetitions of leg press at approximately 75% 1 repetition maximum and 8 sets of 8 repetitions of knee extensions at approximately 80% 1 repetition maximum. L-[ring-2H5]phenylalanine was infused throughout the study for measurement of phenylalanine rates of appearance, disappearance, protein synthesis, and protein breakdown across the leg. Femoral arterial and venous blood samples were collected at rest and during exercise for determination of leg blood flow, concentrations of glucose, lactate, alanine, glutamine, glutamate, leucine, and phenylalanine, and phenylalanine enrichments. Muscle biopsies were obtained at rest and immediately after exercise. Leg blood flow was nearly three times (P
UR - http://www.scopus.com/inward/record.url?scp=4644222520&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00635.2003
DO - 10.1152/japplphysiol.00635.2003
M3 - Article
C2 - 15194677
SN - 1522-1601
VL - 97
SP - 1379
EP - 1386
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
ER -