Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learning

Alessa Hering, Lasse Hansen, Tony C W Mok, Albert C S Chung, Hanna Siebert, Stephanie Hager, Annkristin Lange, Sven Kuckertz, Stefan Heldmann, Wei Shao, Sulaiman Vesal, Mirabela Rusu, Geoffrey Sonn, Theo Estienne, Maria Vakalopoulou, Luyi Han, Yunzhi Huang, Pew-Thian Yap, Mikael Brudfors, Yael BalbastreSamuel Joutard, Marc Modat, Gal Lifshitz, Dan Raviv, Jinxin Lv, Vincent Jaouen, Dimitris Visvikis, Constance Fourcade, Mathieu Rubeaux, Wentao Pan, Zhe Xu, Bailiang Jian, Francesca De Benetti, Marek Wodzinski, Niklas Gunnarsson, Jens Sjolund, Daniel Grzech, Huaqi Qiu, Zeju Li, Alexander Thorley, Jinming Duan, Christoph Grossbrohmer, Andrew Hoopes, Ingerid Reinertsen, Yiming Xiao, Bennett Landman, Yuankai Huo, Keelin Murphy, Nikolas Lessmann, Bram Van Ginneken, Adrian V Dalca, Mattias P Heinrich

Research output: Contribution to journalArticlepeer-review

62 Downloads (Pure)


Image registration is a fundamental medical image analysis task, and a wide variety of approaches have been proposed. However, only a few studies have comprehensively compared medical image registration approaches on a wide range of clinically relevant tasks. This limits the development of registration methods, the adoption of research advances into practice, and a fair benchmark across competing approaches. The Learn2Reg challenge addresses these limitations by providing a multi-task medical image registration data set for comprehensive characterisation of deformable registration algorithms. A continuous evaluation will be possible at https:// learn2reg.grand-challenge.org. Learn2Reg covers a wide range of anatomies (brain, abdomen, and thorax), modalities (ultrasound, CT, MR), availability of annotations, as well as intra- and inter-patient registration evaluation. We established an easily accessible framework for training and validation of 3D registration methods, which enabled the compilation of results of over 65 individual method submissions from more than 20 unique teams. We used a complementary set of metrics, including robustness, accuracy, plausibility, and runtime, enabling unique insight into the current state-of-the-art of medical image registration. This paper describes datasets, tasks, evaluation methods and results of the challenge, as well as results of further analysis of transferability to new datasets, the importance of label supervision, and resulting bias. While no single approach worked best across all tasks, many methodological aspects could be identified that push the performance of medical image registration to new state-of-the-art performance. Furthermore, we demystified the common belief that conventional registration methods have to be much slower than deep-learning-based methods.

Original languageEnglish
Pages (from-to)697-712
Number of pages16
JournalIEEE Transactions on Medical Imaging
Issue number3
Early online date20 Oct 2022
Publication statusPublished - Mar 2023

Bibliographical note

This work was supported in part by the German Federal Ministry of Education and Research under Grant 031L0202B.


  • Medical image registration
  • challenge
  • evaluation


Dive into the research topics of 'Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learning'. Together they form a unique fingerprint.

Cite this