Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling

David Bending; Masahiro Ono

doi:10.1016/j.jaci.2017.03.015

Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling

David Bending, Masahiro Ono

Immunology and Immunotherapy

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease involving skin barrier impairment and immune system dysregulation. The skin barrier is integral for the protection from microbe and allergen infiltration. It is located physically in the outermost layer of the epidermis and comprises terminally differentiated denucleated keratinocytes, the structure of which is dependent on keratin and filaggrin (FLG), and extracellular matrix containing lipids, structural proteins, and the serine protease subgroup kallikreins (KLKs).

Original language	English
Pages (from-to)	1790-1792
Number of pages	3
Journal	Journal of Allergy and Clinical Immunology
Volume	139
Issue number	6
Early online date	7 Apr 2017
DOIs	https://doi.org/10.1016/j.jaci.2017.03.015
Publication status	Published - Jun 2017

Keywords

atopic dermatitis
mathematical models
double switch
disease progression
disease phenotypes
preventive treatment

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http://www.jacionline.org/article/S0091-6749(17)30565-1/fulltextLicence: None: All rights reserved

Cite this

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title = "Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling",

abstract = "Atopic dermatitis (AD) is a chronic inflammatory skin disease involving skin barrier impairment and immune system dysregulation. The skin barrier is integral for the protection from microbe and allergen infiltration. It is located physically in the outermost layer of the epidermis and comprises terminally differentiated denucleated keratinocytes, the structure of which is dependent on keratin and filaggrin (FLG), and extracellular matrix containing lipids, structural proteins, and the serine protease subgroup kallikreins (KLKs).",

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AB - Atopic dermatitis (AD) is a chronic inflammatory skin disease involving skin barrier impairment and immune system dysregulation. The skin barrier is integral for the protection from microbe and allergen infiltration. It is located physically in the outermost layer of the epidermis and comprises terminally differentiated denucleated keratinocytes, the structure of which is dependent on keratin and filaggrin (FLG), and extracellular matrix containing lipids, structural proteins, and the serine protease subgroup kallikreins (KLKs).

KW - atopic dermatitis

KW - mathematical models

KW - double switch

KW - disease progression

KW - disease phenotypes

KW - preventive treatment

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DO - 10.1016/j.jaci.2017.03.015

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ER -

Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling

Abstract

Keywords

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