Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I

SB Kapadia, H Barth, T Baumert, Jane McKeating, FV Chisari

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204 Citations (Scopus)
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Abstract

In the past several years, a number of cellular proteins have been identified as candidate entry receptors for hepatitis C virus (HCV) by using surrogate models of HCV infection. Among these, the tetraspanin CD81 and scavenger receptor B type I (SR-BI), both of which localize to specialized plasma membrane domains enriched in cholesterol, have been suggested to be key players in HCV entry. In the current study, we used a recently developed in vitro HCV infection system to demonstrate that both CD81 and SR-BI are required for authentic HCV infection in vitro, that they function cooperatively to initiate HCV infection, and that CD81-mediated HCV entry is, in part, dependent on membrane cholesterol.
Original languageEnglish
Pages (from-to)374-383
Number of pages10
JournalJournal of virology
Volume81
Issue number1
Early online date25 Oct 2006
DOIs
Publication statusPublished - 25 Oct 2006

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