Inflammation as the nexus:: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Eloise Marriott; Aran Singanayagam; Juma El-Awaisi

doi:10.3389/fcvm.2024.1362564

Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Eloise Marriott, Aran Singanayagam, Juma El-Awaisi^*

^*Corresponding author for this work

Cardiovascular Sciences

Research output: Contribution to journal › Review article › peer-review

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Abstract

Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited. The effectiveness of various inflammatory components in reducing AMI infarct size or slowing COPD progression has shown promise, yet their efficacy in the context of comorbidity with COPD and AMI is not established. This review focuses on the critical importance of both local and systemic inflammation, highlighting it as a key pathophysiological connection between AMI and COPD/AE-COPD.

Original language	English
Article number	1362564
Number of pages	13
Journal	Frontiers in cardiovascular medicine
Volume	11
DOIs	https://doi.org/10.3389/fcvm.2024.1362564
Publication status	Published - 21 Feb 2024

Bibliographical note

Funding
The authors declare financial support was received for the research, authorship, and/or publication of this article.

This work was supported by a British Heart Foundation project grant awarded to J-EA (grant no. 2203809).

Keywords

interleukins
S100A8/A9
inflammation
acute myocardial infarction
anti-inflammatory
chronic obstructive pulmonary disease

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10.3389/fcvm.2024.1362564Licence: Creative Commons: Attribution (CC BY)

MarriottE2024Inflammation.pdfFinal published version, 1.98 MBLicence: Creative Commons: Attribution (CC BY)

BHF Accelerator: Development of an intravital imaging technique of the breathing mouse lungs to investigate cardiopulmonary disease interactions.
Elawaisi, J.
British Heart Foundation
1/10/22 → 30/09/23
Project: Research

Cite this

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title = "Inflammation as the nexus:: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease",

abstract = "Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited. The effectiveness of various inflammatory components in reducing AMI infarct size or slowing COPD progression has shown promise, yet their efficacy in the context of comorbidity with COPD and AMI is not established. This review focuses on the critical importance of both local and systemic inflammation, highlighting it as a key pathophysiological connection between AMI and COPD/AE-COPD.",

keywords = "interleukins, S100A8/A9, inflammation, acute myocardial infarction, anti-inflammatory, chronic obstructive pulmonary disease",

author = "Eloise Marriott and Aran Singanayagam and Juma El-Awaisi",

note = "Funding The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by a British Heart Foundation project grant awarded to J-EA (grant no. 2203809).",

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doi = "10.3389/fcvm.2024.1362564",

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T1 - Inflammation as the nexus:

T2 - exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

AU - Marriott, Eloise

AU - Singanayagam, Aran

AU - El-Awaisi, Juma

N1 - Funding The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by a British Heart Foundation project grant awarded to J-EA (grant no. 2203809).

PY - 2024/2/21

Y1 - 2024/2/21

N2 - Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited. The effectiveness of various inflammatory components in reducing AMI infarct size or slowing COPD progression has shown promise, yet their efficacy in the context of comorbidity with COPD and AMI is not established. This review focuses on the critical importance of both local and systemic inflammation, highlighting it as a key pathophysiological connection between AMI and COPD/AE-COPD.

AB - Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited. The effectiveness of various inflammatory components in reducing AMI infarct size or slowing COPD progression has shown promise, yet their efficacy in the context of comorbidity with COPD and AMI is not established. This review focuses on the critical importance of both local and systemic inflammation, highlighting it as a key pathophysiological connection between AMI and COPD/AE-COPD.

KW - interleukins

KW - S100A8/A9

KW - inflammation

KW - acute myocardial infarction

KW - anti-inflammatory

KW - chronic obstructive pulmonary disease

U2 - 10.3389/fcvm.2024.1362564

DO - 10.3389/fcvm.2024.1362564

M3 - Review article

C2 - 38450367

SN - 2297-055X

VL - 11

JO - Frontiers in cardiovascular medicine

JF - Frontiers in cardiovascular medicine

M1 - 1362564

ER -

Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Abstract

Bibliographical note

Keywords

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Projects

BHF Accelerator: Development of an intravital imaging technique of the breathing mouse lungs to investigate cardiopulmonary disease interactions.

Cite this