Inducible ablation of CD11c+ cells to determine their role in skin wound repair

Zhi Li; Rebecca Lamb; Mark Coles; Clare Bennette; Carrie Ambler

doi:10.1111/imm.13312

Inducible ablation of CD11c⁺ cells to determine their role in skin wound repair

Zhi Li, Rebecca Lamb, Mark Coles, Clare Bennette, Carrie Ambler

Immunology and Immunotherapy

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

72 Downloads (Pure)

Abstract

Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.

Original language	English
Journal	Immunology
Early online date	27 Jan 2021
DOIs	https://doi.org/10.1111/imm.13312
Publication status	E-pub ahead of print - 27 Jan 2021

Keywords

CD11c
dendritic cells
Langerhans cells
skin
wound repair

Access to Document

10.1111/imm.13312Licence: Creative Commons: Attribution (CC BY)

LiZ2021Inducible Final published version, 683 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Inducible ablation of CD11c+ cells to determine their role in skin wound repair",

abstract = "Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.",

keywords = "CD11c, dendritic cells, Langerhans cells, skin, wound repair",

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T1 - Inducible ablation of CD11c+ cells to determine their role in skin wound repair

AU - Li, Zhi

AU - Lamb, Rebecca

AU - Coles, Mark

AU - Bennette, Clare

AU - Ambler, Carrie

PY - 2021/1/27

Y1 - 2021/1/27

N2 - Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.

AB - Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.

KW - CD11c

KW - dendritic cells

KW - Langerhans cells

KW - skin

KW - wound repair

U2 - 10.1111/imm.13312

DO - 10.1111/imm.13312

M3 - Letter

JO - Immunology

JF - Immunology

SN - 0019-2805

ER -