Abstract
Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.
Original language | English |
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Journal | Immunology |
Early online date | 27 Jan 2021 |
DOIs | |
Publication status | E-pub ahead of print - 27 Jan 2021 |
Keywords
- CD11c
- dendritic cells
- Langerhans cells
- skin
- wound repair