Inducible ablation of CD11c+ cells to determine their role in skin wound repair

Zhi Li, Rebecca Lamb, Mark Coles, Clare Bennette, Carrie Ambler

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)
113 Downloads (Pure)

Abstract

Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.
Original languageEnglish
Pages (from-to)105-111
JournalImmunology
Volume163
Issue number1
Early online date27 Jan 2021
DOIs
Publication statusE-pub ahead of print - 27 Jan 2021

Keywords

  • CD11c
  • Langerhans cells
  • dendritic cells
  • skin
  • wound repair

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