Independent cellular processes for hippocampal memory consolidation and reconsolidation

Jonathan L C Lee, Barry J Everitt, Kerrie L Thomas

Research output: Contribution to journalArticlepeer-review

615 Citations (Scopus)
6 Downloads (Pure)


The idea that new memories undergo a time-dependent consolidation process after acquisition has received considerable experimental support. More controversial has been the demonstration that established memories, once recalled, become labile and sensitive to disruption, requiring "reconsolidation" to become permanent. By infusing antisense oligodeoxynucleotides into the hippocampus of rats, we show that consolidation and reconsolidation are doubly dissociable component processes of memory. Consolidation involves brain-derived neurotrophic factor (BDNF) but not the transcription factor Zif268, whereas reconsolidation recruits Zif268 but not BDNF. These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory.
Original languageEnglish
Pages (from-to)839-43
Number of pages5
Issue number5672
Publication statusPublished - 2004


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