Increased hepcidin expression in colorectal carcinogenesis.

Douglas Ward; K Roberts; Matthew Brookes; Howard Joy; Ashley Martin; Tariq Ismail; Robert Spychal; Tariq Iqbal; Chris Tselepis

doi:10.3748/wjg.14.1339

Increased hepcidin expression in colorectal carcinogenesis.

Douglas Ward, K Roberts, Matthew Brookes, Howard Joy, Ashley Martin, Tariq Ismail, Robert Spychal, Tariq Iqbal, Chris Tselepis

Research output: Contribution to journal › Article

78 Citations (Scopus)

Abstract

AIM: To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using immunohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was positively associated with increasing T-stage of colorectal cancer (P

Original language	English
Pages (from-to)	1339-45
Number of pages	7
Journal	World Journal of Gastroenterology
Volume	14
Issue number	9
DOIs	https://doi.org/10.3748/wjg.14.1339
Publication status	Published - 7 Mar 2008

Keywords

mass spectrometry
anaemia
hepcidin
colon
iron
cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3748/wjg.14.1339

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title = "Increased hepcidin expression in colorectal carcinogenesis.",

abstract = "AIM: To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using immunohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was positively associated with increasing T-stage of colorectal cancer (P",

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AU - Ward, Douglas

AU - Roberts, K

AU - Brookes, Matthew

AU - Joy, Howard

AU - Martin, Ashley

AU - Ismail, Tariq

AU - Spychal, Robert

AU - Iqbal, Tariq

AU - Tselepis, Chris

PY - 2008/3/7

Y1 - 2008/3/7

N2 - AIM: To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using immunohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was positively associated with increasing T-stage of colorectal cancer (P

AB - AIM: To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using immunohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was positively associated with increasing T-stage of colorectal cancer (P

KW - mass spectrometry

KW - anaemia

KW - hepcidin

KW - colon

KW - iron

KW - cancer

U2 - 10.3748/wjg.14.1339

DO - 10.3748/wjg.14.1339

M3 - Article

C2 - 18322945

VL - 14

SP - 1339

EP - 1345

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 9

ER -

Increased hepcidin expression in colorectal carcinogenesis.

Abstract

Keywords

UN SDGs

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