Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Archana Panikkar; Corey Smith; Andrew Hislop; Nick Tellam; Vijayendra Dasari; Kristin A Hogquist; Michelle Wykes; Denis J Moss; Alan Rickinson; Henry H Balfour; Rajiv Khanna

doi:10.1128/JVI.01293-15

Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Archana Panikkar, Corey Smith, Andrew Hislop, Nick Tellam, Vijayendra Dasari, Kristin A Hogquist, Michelle Wykes, Denis J Moss, Alan Rickinson, Henry H Balfour, Rajiv Khanna

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Abstract

Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

Original language	English
Pages (from-to)	9137-9141
Number of pages	5
Journal	Journal of virology
Volume	89
Issue number	17
Early online date	24 Jun 2015
DOIs	https://doi.org/10.1128/JVI.01293-15
Publication status	Published - Sept 2015

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Panikkar_et_al_Impaired_epstein_barr_J. Virol.-2015
Checked for eligibility: 22/01/2016
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Panikkar, A., Smith, C., Hislop, A., Tellam, N., Dasari, V., Hogquist, K. A., Wykes, M., Moss, D. J., Rickinson, A., Balfour, H. H., & Khanna, R. (2015). Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction. Journal of virology, 89(17), 9137-9141. https://doi.org/10.1128/JVI.01293-15

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title = "Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction",

abstract = "Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.",

author = "Archana Panikkar and Corey Smith and Andrew Hislop and Nick Tellam and Vijayendra Dasari and Hogquist, {Kristin A} and Michelle Wykes and Moss, {Denis J} and Alan Rickinson and Balfour, {Henry H} and Rajiv Khanna",

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Panikkar, A, Smith, C, Hislop, A, Tellam, N, Dasari, V, Hogquist, KA, Wykes, M, Moss, DJ, Rickinson, A, Balfour, HH & Khanna, R 2015, 'Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction', Journal of virology, vol. 89, no. 17, pp. 9137-9141. https://doi.org/10.1128/JVI.01293-15

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T1 - Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

AU - Panikkar, Archana

AU - Smith, Corey

AU - Hislop, Andrew

AU - Tellam, Nick

AU - Dasari, Vijayendra

AU - Hogquist, Kristin A

AU - Wykes, Michelle

AU - Moss, Denis J

AU - Rickinson, Alan

AU - Balfour, Henry H

AU - Khanna, Rajiv

PY - 2015/9

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N2 - Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

AB - Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

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DO - 10.1128/JVI.01293-15

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C2 - 26109734

SN - 0022-538X

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EP - 9141

JO - Journal of virology

JF - Journal of virology

IS - 17

ER -

Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Abstract

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