Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study

D Araiza-Garaygordobil; C Montalto; P Martinez-Amezcua; A Cabello-Lopez; R Gopar-Nieto; R Alabrese; A Almaghraby; S Catoya-Villa; M Chacon-Diaz; C C Kaufmann; M Corbi-Pascual; P Deharo; M El-Tahlawi; A Elgohari-Abdelwahab; F Guerra; M Jarakovic; E Martinez-Gomez; L Moderato; S Montero; P Morejon-Barragan; A M Omar; P Jorge-Pérez; P Przybyło; E Selim; U Y Sinan; M Stratinaki; O Tica; M Trêpa; A Uribarri; J Uzokov; K Wilk; K Czerwińska-Jelonkiewicz; A Sionis; M Gierlotka; S Leonardi; K A Krychtiuk; G Tavazzi

doi:10.1093/qjmed/hcab013

Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study

D Araiza-Garaygordobil, C Montalto, P Martinez-Amezcua, A Cabello-Lopez, R Gopar-Nieto, R Alabrese, A Almaghraby, S Catoya-Villa, M Chacon-Diaz, C C Kaufmann, M Corbi-Pascual, P Deharo, M El-Tahlawi, A Elgohari-Abdelwahab, F Guerra, M Jarakovic, E Martinez-Gomez, L Moderato, S Montero, P Morejon-BarraganA M Omar, P Jorge-Pérez, P Przybyło, E Selim, U Y Sinan, M Stratinaki, O Tica, M Trêpa, A Uribarri, J Uzokov, K Wilk, K Czerwińska-Jelonkiewicz, A Sionis, M Gierlotka, S Leonardi, K A Krychtiuk, G Tavazzi

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background: COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS).

Aim: To describe ACS hospitalizations, management, and complication rate before and after the COVID-19 pandemic was declared.

Design: Ecological retrospective study. Methods: We analyzed aggregated epidemiological data of all patients > 18 years old admitted for ACS in twenty-nine hub cardiac centers from 17 Countries across 4 continents, from December 1st, 2019 to April 15th, 2020. Data from December 2018 to April 2019 were used as historical period.

Results: A significant overall trend for reduction in the weekly number of ACS hospitalizations was observed (20.2%; 95% confidence interval CI [1.6, 35.4] P = 0.04). The incidence rate reached a 54% reduction during the second week of April (incidence rate ratio: 0.46, 95% CI [0.36, 0.58]) and was also significant when compared to the same months in 2019 (March and April, respectively IRR: 0.56, 95%CI [0.48, 0.67]; IRR: 0.43, 95%CI [0.32, 0.58] p < 0.001). A significant increase in door-to-balloon, door-to-needle, and total ischemic time (p
Conclusions: Our results confirm that COVID-19 pandemic was associated with a significant decrease in ACS hospitalizations rate, an increase in total ischemic time and a higher rate of mechanical complications on a international scale.

Original language	English
Pages (from-to)	642–647
Number of pages	6
Journal	QJM: An International Journal of Medicine
Volume	114
Issue number	9
Early online date	24 Jan 2021
DOIs	https://doi.org/10.1093/qjmed/hcab013
Publication status	Published - Sept 2021

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Araiza-Garaygordobil, D., Montalto, C., Martinez-Amezcua, P., Cabello-Lopez, A., Gopar-Nieto, R., Alabrese, R., Almaghraby, A., Catoya-Villa, S., Chacon-Diaz, M., Kaufmann, C. C., Corbi-Pascual, M., Deharo, P., El-Tahlawi, M., Elgohari-Abdelwahab, A., Guerra, F., Jarakovic, M., Martinez-Gomez, E., Moderato, L., Montero, S., ... Tavazzi, G. (2021). Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study. QJM: An International Journal of Medicine, 114(9), 642–647. https://doi.org/10.1093/qjmed/hcab013

@article{57e49913f98f43c2bace3cff6684e534,

title = "Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study",

abstract = "Background: COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS).Aim: To describe ACS hospitalizations, management, and complication rate before and after the COVID-19 pandemic was declared.Design: Ecological retrospective study. Methods: We analyzed aggregated epidemiological data of all patients > 18 years old admitted for ACS in twenty-nine hub cardiac centers from 17 Countries across 4 continents, from December 1st, 2019 to April 15th, 2020. Data from December 2018 to April 2019 were used as historical period.Results: A significant overall trend for reduction in the weekly number of ACS hospitalizations was observed (20.2%; 95% confidence interval CI [1.6, 35.4] P = 0.04). The incidence rate reached a 54% reduction during the second week of April (incidence rate ratio: 0.46, 95% CI [0.36, 0.58]) and was also significant when compared to the same months in 2019 (March and April, respectively IRR: 0.56, 95%CI [0.48, 0.67]; IRR: 0.43, 95%CI [0.32, 0.58] p < 0.001). A significant increase in door-to-balloon, door-to-needle, and total ischemic time (p Conclusions: Our results confirm that COVID-19 pandemic was associated with a significant decrease in ACS hospitalizations rate, an increase in total ischemic time and a higher rate of mechanical complications on a international scale.",

author = "D Araiza-Garaygordobil and C Montalto and P Martinez-Amezcua and A Cabello-Lopez and R Gopar-Nieto and R Alabrese and A Almaghraby and S Catoya-Villa and M Chacon-Diaz and Kaufmann, {C C} and M Corbi-Pascual and P Deharo and M El-Tahlawi and A Elgohari-Abdelwahab and F Guerra and M Jarakovic and E Martinez-Gomez and L Moderato and S Montero and P Morejon-Barragan and Omar, {A M} and P Jorge-P{\'e}rez and P Przyby{\l}o and E Selim and Sinan, {U Y} and M Stratinaki and O Tica and M Tr{\^e}pa and A Uribarri and J Uzokov and K Wilk and K Czerwi{\'n}ska-Jelonkiewicz and A Sionis and M Gierlotka and S Leonardi and Krychtiuk, {K A} and G Tavazzi",

year = "2021",

month = sep,

doi = "10.1093/qjmed/hcab013",

language = "English",

volume = "114",

pages = "642–647",

journal = "QJM: An International Journal of Medicine",

issn = "1460-2725",

publisher = "Oxford University Press",

number = "9",

}

Araiza-Garaygordobil, D, Montalto, C, Martinez-Amezcua, P, Cabello-Lopez, A, Gopar-Nieto, R, Alabrese, R, Almaghraby, A, Catoya-Villa, S, Chacon-Diaz, M, Kaufmann, CC, Corbi-Pascual, M, Deharo, P, El-Tahlawi, M, Elgohari-Abdelwahab, A, Guerra, F, Jarakovic, M, Martinez-Gomez, E, Moderato, L, Montero, S, Morejon-Barragan, P, Omar, AM, Jorge-Pérez, P, Przybyło, P, Selim, E, Sinan, UY, Stratinaki, M, Tica, O, Trêpa, M, Uribarri, A, Uzokov, J, Wilk, K, Czerwińska-Jelonkiewicz, K, Sionis, A, Gierlotka, M, Leonardi, S, Krychtiuk, KA & Tavazzi, G 2021, 'Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study', QJM: An International Journal of Medicine, vol. 114, no. 9, pp. 642–647. https://doi.org/10.1093/qjmed/hcab013

TY - JOUR

T1 - Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes

T2 - a multinational study

AU - Araiza-Garaygordobil, D

AU - Montalto, C

AU - Martinez-Amezcua, P

AU - Cabello-Lopez, A

AU - Gopar-Nieto, R

AU - Alabrese, R

AU - Almaghraby, A

AU - Catoya-Villa, S

AU - Chacon-Diaz, M

AU - Kaufmann, C C

AU - Corbi-Pascual, M

AU - Deharo, P

AU - El-Tahlawi, M

AU - Elgohari-Abdelwahab, A

AU - Guerra, F

AU - Jarakovic, M

AU - Martinez-Gomez, E

AU - Moderato, L

AU - Montero, S

AU - Morejon-Barragan, P

AU - Omar, A M

AU - Jorge-Pérez, P

AU - Przybyło, P

AU - Selim, E

AU - Sinan, U Y

AU - Stratinaki, M

AU - Tica, O

AU - Trêpa, M

AU - Uribarri, A

AU - Uzokov, J

AU - Wilk, K

AU - Czerwińska-Jelonkiewicz, K

AU - Sionis, A

AU - Gierlotka, M

AU - Leonardi, S

AU - Krychtiuk, K A

AU - Tavazzi, G

PY - 2021/9

Y1 - 2021/9

N2 - Background: COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS).Aim: To describe ACS hospitalizations, management, and complication rate before and after the COVID-19 pandemic was declared.Design: Ecological retrospective study. Methods: We analyzed aggregated epidemiological data of all patients > 18 years old admitted for ACS in twenty-nine hub cardiac centers from 17 Countries across 4 continents, from December 1st, 2019 to April 15th, 2020. Data from December 2018 to April 2019 were used as historical period.Results: A significant overall trend for reduction in the weekly number of ACS hospitalizations was observed (20.2%; 95% confidence interval CI [1.6, 35.4] P = 0.04). The incidence rate reached a 54% reduction during the second week of April (incidence rate ratio: 0.46, 95% CI [0.36, 0.58]) and was also significant when compared to the same months in 2019 (March and April, respectively IRR: 0.56, 95%CI [0.48, 0.67]; IRR: 0.43, 95%CI [0.32, 0.58] p < 0.001). A significant increase in door-to-balloon, door-to-needle, and total ischemic time (p Conclusions: Our results confirm that COVID-19 pandemic was associated with a significant decrease in ACS hospitalizations rate, an increase in total ischemic time and a higher rate of mechanical complications on a international scale.

AB - Background: COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS).Aim: To describe ACS hospitalizations, management, and complication rate before and after the COVID-19 pandemic was declared.Design: Ecological retrospective study. Methods: We analyzed aggregated epidemiological data of all patients > 18 years old admitted for ACS in twenty-nine hub cardiac centers from 17 Countries across 4 continents, from December 1st, 2019 to April 15th, 2020. Data from December 2018 to April 2019 were used as historical period.Results: A significant overall trend for reduction in the weekly number of ACS hospitalizations was observed (20.2%; 95% confidence interval CI [1.6, 35.4] P = 0.04). The incidence rate reached a 54% reduction during the second week of April (incidence rate ratio: 0.46, 95% CI [0.36, 0.58]) and was also significant when compared to the same months in 2019 (March and April, respectively IRR: 0.56, 95%CI [0.48, 0.67]; IRR: 0.43, 95%CI [0.32, 0.58] p < 0.001). A significant increase in door-to-balloon, door-to-needle, and total ischemic time (p Conclusions: Our results confirm that COVID-19 pandemic was associated with a significant decrease in ACS hospitalizations rate, an increase in total ischemic time and a higher rate of mechanical complications on a international scale.

U2 - 10.1093/qjmed/hcab013

DO - 10.1093/qjmed/hcab013

M3 - Article

SN - 1460-2725

VL - 114

SP - 642

EP - 647

JO - QJM: An International Journal of Medicine

JF - QJM: An International Journal of Medicine

IS - 9

ER -

Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study

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