Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

DD Olio, G Gupte, Khaldoun Sharif, Michael Murphy, Christine Lloyd, Patrick McKiernan, Deirdre Kelly, Susan Beath

Research output: Contribution to journalArticle

6 Citations (Scopus)


BACKGROUND: Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM: To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS: A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function). RESULTS: Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p
Original languageEnglish
Pages (from-to)677-81
Number of pages5
JournalPediatric Transplantation
Issue number6
Publication statusPublished - 1 Sept 2006


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