Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

DD Olio; G Gupte; Khaldoun Sharif; Michael Murphy; Christine Lloyd; Patrick McKiernan; Deirdre Kelly; Susan Beath

doi:10.1111/j.1399-3046.2006.00504.x

Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

DD Olio, G Gupte, Khaldoun Sharif, Michael Murphy, Christine Lloyd, Patrick McKiernan, Deirdre Kelly, Susan Beath

Birmingham Medical School

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

BACKGROUND: Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM: To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS: A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function). RESULTS: Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p

Original language	English
Pages (from-to)	677-81
Number of pages	5
Journal	Pediatric Transplantation
Volume	10
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-3046.2006.00504.x
Publication status	Published - 1 Sept 2006

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title = "Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.",

abstract = "BACKGROUND: Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM: To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS: A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function). RESULTS: Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p",

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TY - JOUR

T1 - Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

AU - Olio, DD

AU - Gupte, G

AU - Sharif, Khaldoun

AU - Murphy, Michael

AU - Lloyd, Christine

AU - McKiernan, Patrick

AU - Kelly, Deirdre

AU - Beath, Susan

PY - 2006/9/1

Y1 - 2006/9/1

N2 - BACKGROUND: Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM: To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS: A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function). RESULTS: Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p

AB - BACKGROUND: Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM: To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS: A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function). RESULTS: Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p

U2 - 10.1111/j.1399-3046.2006.00504.x

DO - 10.1111/j.1399-3046.2006.00504.x

M3 - Article

C2 - 16911490

SN - 1399-3046

VL - 10

SP - 677

EP - 681

JO - Pediatric Transplantation

JF - Pediatric Transplantation

IS - 6

ER -

Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

Abstract

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