Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?

Oliver J Pickles; Lennard Y W Lee; Thomas Starkey; Luke Freeman-Mills; Anna Olsson-Brown; Vinton Cheng; Daniel J Hughes; Alvin Lee; Karin Purshouse; Gary Middleton

doi:10.1038/s41416-020-0930-7

Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?

Oliver J Pickles, Lennard Y W Lee, Thomas Starkey, Luke Freeman-Mills, Anna Olsson-Brown, Vinton Cheng, Daniel J Hughes, Alvin Lee, Karin Purshouse, Gary Middleton

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy agents have the potential to adversely potentiate this phenomenon, requiring careful real-world observation.

Original language	English
Pages (from-to)	691-693
Number of pages	3
Journal	British Journal of Cancer
Volume	123
Issue number	5
DOIs	https://doi.org/10.1038/s41416-020-0930-7
Publication status	Published - Sept 2020

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10.1038/s41416-020-0930-7

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title = "Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?",

abstract = "The rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy agents have the potential to adversely potentiate this phenomenon, requiring careful real-world observation.",

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AU - Freeman-Mills, Luke

AU - Olsson-Brown, Anna

AU - Cheng, Vinton

AU - Hughes, Daniel J

AU - Lee, Alvin

AU - Purshouse, Karin

AU - Middleton, Gary

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AB - The rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy agents have the potential to adversely potentiate this phenomenon, requiring careful real-world observation.

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Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?

Abstract

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