Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry

Harriet Cornwell; Nicola Toschi; Catherine Hamilton-Giachritsis; Marlene Staginnus; Areti Smaragdi; Karen Gonzalez-Madruga; Nuria Mackes; Jack Rogers; Anne Martinelli; Gregor Kohls; Nora Maria Raschle; Kerstin Konrad; Christina Stadler; Christine M Freitag; Stephane A De Brito; Graeme Fairchild

doi:10.1093/scan/nsae006

Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry

Harriet Cornwell, Nicola Toschi, Catherine Hamilton-Giachritsis, Marlene Staginnus, Areti Smaragdi, Karen Gonzalez-Madruga, Nuria Mackes, Jack Rogers, Anne Martinelli, Gregor Kohls, Nora Maria Raschle, Kerstin Konrad, Christina Stadler, Christine M Freitag, Stephane A De Brito, Graeme Fairchild^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

12 Downloads (Pure)

Abstract

Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (M_age = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.

Original language	English
Article number	nsae006
Number of pages	11
Journal	Social Cognitive and Affective Neuroscience
Volume	19
Issue number	1
DOIs	https://doi.org/10.1093/scan/nsae006
Publication status	Published - 27 Jan 2024

Bibliographical note

Funding:
This work was supported in part by grant MR/N0137941/1 for the GW4 BIOMED Medical Research Council Doctoral Training Partnership, awarded to the Universities of Bath, Bristol, Cardiff and Exeter from the Medical Research Council (MRC)/UKRI, and grant ES/P000630/1 for the South-West Doctoral Training Partnership, awarded to the Universities of Bath, Bristol, Exeter, Plymouth and West of England (UWE) from the Economic and Social Research Council (ESRC)/UKRI. These grants funded PhD studentships awarded to H.C. and M.S. The FemNAT-CD study was funded by the European Commission’s Seventh Framework Programme (FP7/2007-2013, grant number 602 407; coordinator C.M. Freitag). N.M.R. received grant support as a Jacobs Foundation Early Career Fellow 2017–2019 (grant no. 2016 1217 13).

Keywords

resilience
adolescent
brain structure
adversity
cortical thickness

Access to Document

10.1093/scan/nsae006Licence: Creative Commons: Attribution (CC BY)

CornwellH2024IdentifyingFinal published version, 12.6 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

Cornwell, H., Toschi, N., Hamilton-Giachritsis, C., Staginnus, M., Smaragdi, A., Gonzalez-Madruga, K., Mackes, N., Rogers, J., Martinelli, A., Kohls, G., Raschle, N. M., Konrad, K., Stadler, C., Freitag, C. M., De Brito, S. A., & Fairchild, G. (2024). Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry. Social Cognitive and Affective Neuroscience, 19(1), Article nsae006. https://doi.org/10.1093/scan/nsae006

@article{65d1475cf7c043459ac1a4f737ca37b6,

title = "Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry",

abstract = "Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.",

keywords = "resilience, adolescent, brain structure, adversity, cortical thickness",

author = "Harriet Cornwell and Nicola Toschi and Catherine Hamilton-Giachritsis and Marlene Staginnus and Areti Smaragdi and Karen Gonzalez-Madruga and Nuria Mackes and Jack Rogers and Anne Martinelli and Gregor Kohls and Raschle, {Nora Maria} and Kerstin Konrad and Christina Stadler and Freitag, {Christine M} and {De Brito}, {Stephane A} and Graeme Fairchild",

note = "Funding: This work was supported in part by grant MR/N0137941/1 for the GW4 BIOMED Medical Research Council Doctoral Training Partnership, awarded to the Universities of Bath, Bristol, Cardiff and Exeter from the Medical Research Council (MRC)/UKRI, and grant ES/P000630/1 for the South-West Doctoral Training Partnership, awarded to the Universities of Bath, Bristol, Exeter, Plymouth and West of England (UWE) from the Economic and Social Research Council (ESRC)/UKRI. These grants funded PhD studentships awarded to H.C. and M.S. The FemNAT-CD study was funded by the European Commission{\textquoteright}s Seventh Framework Programme (FP7/2007-2013, grant number 602 407; coordinator C.M. Freitag). N.M.R. received grant support as a Jacobs Foundation Early Career Fellow 2017–2019 (grant no. 2016 1217 13).",

year = "2024",

month = jan,

day = "27",

doi = "10.1093/scan/nsae006",

language = "English",

volume = "19",

journal = "Social Cognitive and Affective Neuroscience",

issn = "1749-5016",

publisher = "Oxford University Press",

number = "1",

}

Cornwell, H, Toschi, N, Hamilton-Giachritsis, C, Staginnus, M, Smaragdi, A, Gonzalez-Madruga, K, Mackes, N, Rogers, J, Martinelli, A, Kohls, G, Raschle, NM, Konrad, K, Stadler, C, Freitag, CM, De Brito, SA & Fairchild, G 2024, 'Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry', Social Cognitive and Affective Neuroscience, vol. 19, no. 1, nsae006. https://doi.org/10.1093/scan/nsae006

TY - JOUR

T1 - Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry

AU - Cornwell, Harriet

AU - Toschi, Nicola

AU - Hamilton-Giachritsis, Catherine

AU - Staginnus, Marlene

AU - Smaragdi, Areti

AU - Gonzalez-Madruga, Karen

AU - Mackes, Nuria

AU - Rogers, Jack

AU - Martinelli, Anne

AU - Kohls, Gregor

AU - Raschle, Nora Maria

AU - Konrad, Kerstin

AU - Stadler, Christina

AU - Freitag, Christine M

AU - De Brito, Stephane A

AU - Fairchild, Graeme

N1 - Funding: This work was supported in part by grant MR/N0137941/1 for the GW4 BIOMED Medical Research Council Doctoral Training Partnership, awarded to the Universities of Bath, Bristol, Cardiff and Exeter from the Medical Research Council (MRC)/UKRI, and grant ES/P000630/1 for the South-West Doctoral Training Partnership, awarded to the Universities of Bath, Bristol, Exeter, Plymouth and West of England (UWE) from the Economic and Social Research Council (ESRC)/UKRI. These grants funded PhD studentships awarded to H.C. and M.S. The FemNAT-CD study was funded by the European Commission’s Seventh Framework Programme (FP7/2007-2013, grant number 602 407; coordinator C.M. Freitag). N.M.R. received grant support as a Jacobs Foundation Early Career Fellow 2017–2019 (grant no. 2016 1217 13).

PY - 2024/1/27

Y1 - 2024/1/27

N2 - Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.

AB - Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.

KW - resilience

KW - adolescent

KW - brain structure

KW - adversity

KW - cortical thickness

U2 - 10.1093/scan/nsae006

DO - 10.1093/scan/nsae006

M3 - Article

SN - 1749-5016

VL - 19

JO - Social Cognitive and Affective Neuroscience

JF - Social Cognitive and Affective Neuroscience

IS - 1

M1 - nsae006

ER -

Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this