Hyperspectral terahertz imaging for human bone biometrics

Suzanna Freer; Cong Sui; Pavel Penchev; Stefan Dimov; Andrei Gorodetsky; Stephen M. Hanham; Liam M. Grover; Miguel Navarro-Ciá

doi:10.1117/12.2595921

Hyperspectral terahertz imaging for human bone biometrics

Suzanna Freer, Cong Sui, Pavel Penchev, Stefan Dimov, Andrei Gorodetsky, Stephen M. Hanham, Liam M. Grover, Miguel Navarro-Ciá^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The realisation of hyperspectral terahertz imaging is a significant step towards understanding of the life sciences on all scales. A key to this understanding is the retrieval of dielectric properties from such images, a task which is plagued by experimental limitations, challenging the terahertz community for more than two decades. In this contribution, we propose a new combined retrieval methodology to overcome misalignments and Fabry-Pérot effects on the extraction of the dielectric properties of human bone samples through the combination of the Kramers-Kronig relations and Fabry-Pérot reflection modelling. Results extracted from ∼100 μm human bone slices composed largely of collagen are consistent with those measured for pristine collagen samples. This represents another stepping-stone towards the adoption of terahertz imaging into pre- A nd clinical practice.

Original language	English
Title of host publication	Terahertz Emitters, Receivers, and Applications XII
Editors	Manijeh Razeghi, Alexei N. Baranov
Publisher	SPIE
ISBN (Electronic)	9781510644939
ISBN (Print)	9781510644922
DOIs	https://doi.org/10.1117/12.2595921
Publication status	Published - 1 Aug 2021
Event	Terahertz Emitters, Receivers, and Applications XII 2021 - San Diego, United States Duration: 1 Aug 2021 → 5 Aug 2021

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11827
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Terahertz Emitters, Receivers, and Applications XII 2021
Country/Territory	United States
City	San Diego
Period	1/08/21 → 5/08/21

Bibliographical note

Funding Information:
The authors would like to thank V. Lucarini et al. for the use of their Kramers-Kronig MATLAB scripts.18 This work was supported in part by the EPSRC [Grant Nos. EP/S018395/1 and EP/V001655/1] and the Royal Society [Grant Nos. IES/R3/183131 and IEC/NSFC/191104]. S. Freer was supported by the University of Birmingham [PhD studentship UKRI Project Reference 2137478]. S. M. Hanham and M. Navarro-Ćıa were supported by the University of Birmingham [Birmingham Fellowship].

Publisher Copyright:
© 2021 SPIE.

Keywords

dielectric imaging
dielectric property extraction
Fabry-Perot effects
human bone
Kramers-Kronig relations
Terahertz
time domain spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.2595921

1 Finished
1 Active

Terahertz Lab-on-a-Chip for Bio-liquid Analysis
Hanham, S.
Engineering & Physical Science Research Council
1/02/21 → 15/05/24
Project: Research Councils
THEIA: fast super-resolution TeraHErtz mIcroscopy for nAtural Sciences
Navarro-Cia, M.
Engineering & Physical Science Research Council
1/08/19 → 31/03/21
Project: Research

Cite this

Freer, S., Sui, C., Penchev, P., Dimov, S., Gorodetsky, A., Hanham, S. M., Grover, L. M., & Navarro-Ciá, M. (2021). Hyperspectral terahertz imaging for human bone biometrics. In M. Razeghi, & A. N. Baranov (Eds.), Terahertz Emitters, Receivers, and Applications XII Article 118270T (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11827). SPIE. https://doi.org/10.1117/12.2595921

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abstract = "The realisation of hyperspectral terahertz imaging is a significant step towards understanding of the life sciences on all scales. A key to this understanding is the retrieval of dielectric properties from such images, a task which is plagued by experimental limitations, challenging the terahertz community for more than two decades. In this contribution, we propose a new combined retrieval methodology to overcome misalignments and Fabry-P{\'e}rot effects on the extraction of the dielectric properties of human bone samples through the combination of the Kramers-Kronig relations and Fabry-P{\'e}rot reflection modelling. Results extracted from ∼100 μm human bone slices composed largely of collagen are consistent with those measured for pristine collagen samples. This represents another stepping-stone towards the adoption of terahertz imaging into pre- A nd clinical practice.",

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note = "Funding Information: The authors would like to thank V. Lucarini et al. for the use of their Kramers-Kronig MATLAB scripts.18 This work was supported in part by the EPSRC [Grant Nos. EP/S018395/1 and EP/V001655/1] and the Royal Society [Grant Nos. IES/R3/183131 and IEC/NSFC/191104]. S. Freer was supported by the University of Birmingham [PhD studentship UKRI Project Reference 2137478]. S. M. Hanham and M. Navarro-{\'C}ıa were supported by the University of Birmingham [Birmingham Fellowship]. Publisher Copyright: {\textcopyright} 2021 SPIE.; Terahertz Emitters, Receivers, and Applications XII 2021 ; Conference date: 01-08-2021 Through 05-08-2021",

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Freer, S, Sui, C , Penchev, P , Dimov, S, Gorodetsky, A, Hanham, SM , Grover, LM & Navarro-Ciá, M 2021, Hyperspectral terahertz imaging for human bone biometrics. in M Razeghi & AN Baranov (eds), Terahertz Emitters, Receivers, and Applications XII., 118270T, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11827, SPIE, Terahertz Emitters, Receivers, and Applications XII 2021, San Diego, United States, 1/08/21. https://doi.org/10.1117/12.2595921

Hyperspectral terahertz imaging for human bone biometrics. / Freer, Suzanna; Sui, Cong ; Penchev, Pavel et al.
Terahertz Emitters, Receivers, and Applications XII. ed. / Manijeh Razeghi; Alexei N. Baranov. SPIE, 2021. 118270T (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11827).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Grover, Liam M.

AU - Navarro-Ciá, Miguel

N1 - Funding Information: The authors would like to thank V. Lucarini et al. for the use of their Kramers-Kronig MATLAB scripts.18 This work was supported in part by the EPSRC [Grant Nos. EP/S018395/1 and EP/V001655/1] and the Royal Society [Grant Nos. IES/R3/183131 and IEC/NSFC/191104]. S. Freer was supported by the University of Birmingham [PhD studentship UKRI Project Reference 2137478]. S. M. Hanham and M. Navarro-Ćıa were supported by the University of Birmingham [Birmingham Fellowship]. Publisher Copyright: © 2021 SPIE.

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N2 - The realisation of hyperspectral terahertz imaging is a significant step towards understanding of the life sciences on all scales. A key to this understanding is the retrieval of dielectric properties from such images, a task which is plagued by experimental limitations, challenging the terahertz community for more than two decades. In this contribution, we propose a new combined retrieval methodology to overcome misalignments and Fabry-Pérot effects on the extraction of the dielectric properties of human bone samples through the combination of the Kramers-Kronig relations and Fabry-Pérot reflection modelling. Results extracted from ∼100 μm human bone slices composed largely of collagen are consistent with those measured for pristine collagen samples. This represents another stepping-stone towards the adoption of terahertz imaging into pre- A nd clinical practice.

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KW - time domain spectroscopy

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DO - 10.1117/12.2595921

M3 - Conference contribution

AN - SCOPUS:85116067340

SN - 9781510644922

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Terahertz Emitters, Receivers, and Applications XII

A2 - Razeghi, Manijeh

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PB - SPIE

T2 - Terahertz Emitters, Receivers, and Applications XII 2021

Y2 - 1 August 2021 through 5 August 2021

ER -

Hyperspectral terahertz imaging for human bone biometrics

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Projects

Terahertz Lab-on-a-Chip for Bio-liquid Analysis

THEIA: fast super-resolution TeraHErtz mIcroscopy for nAtural Sciences

Cite this