Abstract
OBJECTIVE: Granuloma-forming diseases such as sarcoidosis are associated with extrarenal synthesis of 1,25-dihydroxyvitamin D [1,25(OH)₂D]. We describe a case of extensive skin lesions associated with mineral oil injections in which we provide evidence for cutaneous granuloma synthesis of 1,25(OH)₂D in the pathogenesis of the patient's hypercalcemia.
METHODS: Analysis of expression of the 25(OH)D-1a-hydroxylase (1-a OHase [CYP27b1]) was carried out by immunohistochemical analysis of involved skin.
RESULTS: In involved skin, expression of CYP27b1 was found in the dermis, where it is not normally expressed. Successful management of hypercalcemia was achieved with glucocorticoids.
CONCLUSIONS: Hypercalcemia associated with mineral oil induced skin lesions is likely driven by unregulated expression of CYP27b1 by inflammatory monocytes and macrophages infiltrating the dermis.
| Original language | English |
|---|---|
| Pages (from-to) | e50-6 |
| Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 23 Jan 2013 |
Keywords
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- Antineoplastic Agents, Hormonal
- Cellulitis
- Cosmetic Techniques
- Glucocorticoids
- Granuloma
- Humans
- Hypercalcemia
- Injections, Subcutaneous
- Lower Extremity
- Macrophages
- Male
- Middle Aged
- Mineral Oil
- Monocytes
- Postoperative Complications
- Prednisone
- Sclerosis
- Skin
- Skin Neoplasms
- Skin Transplantation
- Treatment Outcome