Human pancreas development

Rachel E. Jennings; Andrew A. Berry; James P. Strutt; David T. Gerrard; Neil A. Hanley

doi:10.1242/dev.120063

Human pancreas development

Rachel E. Jennings^*, Andrew A. Berry, James P. Strutt, David T. Gerrard, Neil A. Hanley

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

191 Citations (Scopus)

Abstract

A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

Original language	English
Pages (from-to)	3126-3137
Number of pages	12
Journal	Development (Cambridge)
Volume	142
Issue number	18
DOIs	https://doi.org/10.1242/dev.120063
Publication status	Published - 23 Sept 2015

Bibliographical note

Publisher Copyright:
© 2015, Published by The Company of Biologists Ltd.

Keywords

Development
Embryo
Endoderm
Fetal
Foregut
Gestation
Human
Liver
Pancreas
Stem cells
Transcription factor
β-cells

ASJC Scopus subject areas

Molecular Biology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1242/dev.120063

Cite this

@article{9273b54fb7ae47d3b8f997f07cde78ad,

title = "Human pancreas development",

abstract = "A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.",

keywords = "Development, Embryo, Endoderm, Fetal, Foregut, Gestation, Human, Liver, Pancreas, Stem cells, Transcription factor, β-cells",

author = "Jennings, {Rachel E.} and Berry, {Andrew A.} and Strutt, {James P.} and Gerrard, {David T.} and Hanley, {Neil A.}",

note = "Publisher Copyright: {\textcopyright} 2015, Published by The Company of Biologists Ltd.",

year = "2015",

month = sep,

day = "23",

doi = "10.1242/dev.120063",

language = "English",

volume = "142",

pages = "3126--3137",

journal = "Development (Cambridge)",

issn = "0950-1991",

publisher = "The Company of Biologists Ltd.",

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T1 - Human pancreas development

AU - Jennings, Rachel E.

AU - Berry, Andrew A.

AU - Strutt, James P.

AU - Gerrard, David T.

AU - Hanley, Neil A.

PY - 2015/9/23

Y1 - 2015/9/23

N2 - A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

AB - A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

KW - Development

KW - Embryo

KW - Endoderm

KW - Fetal

KW - Foregut

KW - Gestation

KW - Human

KW - Liver

KW - Pancreas

KW - Stem cells

KW - Transcription factor

KW - β-cells

UR - http://www.scopus.com/inward/record.url?scp=84942162894&partnerID=8YFLogxK

U2 - 10.1242/dev.120063

DO - 10.1242/dev.120063

M3 - Review article

C2 - 26395141

AN - SCOPUS:84942162894

SN - 0950-1991

VL - 142

SP - 3126

EP - 3137

JO - Development (Cambridge)

JF - Development (Cambridge)

IS - 18

ER -

Human pancreas development

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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