Abstract
A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.
Original language | English |
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Pages (from-to) | 3126-3137 |
Number of pages | 12 |
Journal | Development (Cambridge) |
Volume | 142 |
Issue number | 18 |
DOIs | |
Publication status | Published - 23 Sept 2015 |
Bibliographical note
Publisher Copyright:© 2015, Published by The Company of Biologists Ltd.
Keywords
- Development
- Embryo
- Endoderm
- Fetal
- Foregut
- Gestation
- Human
- Liver
- Pancreas
- Stem cells
- Transcription factor
- β-cells
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology