Homozygous deletions at 3p12 in breast and lung cancer

V Sundaresan; G Chung; A Heppell-Parton; Jie Xiong; C Grundy; I Roberts; L James; A Cahn; J Douglas; MI Minna; Y Sekido; MI Lerman; Farida Latif; J Bergh; H Li; N Lowe; D Ogilvie; P Rabbitts

doi:10.1038/sj.onc.1202103

Homozygous deletions at 3p12 in breast and lung cancer

V Sundaresan, G Chung, A Heppell-Parton, Jie Xiong, C Grundy, I Roberts, L James, A Cahn, J Douglas, MI Minna, Y Sekido, MI Lerman, Farida Latif, J Bergh, H Li, N Lowe, D Ogilvie, P Rabbitts

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Abstract

We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.

Original language	English
Pages (from-to)	1723-9
Number of pages	7
Journal	Oncogene
Volume	17
Issue number	13
Early online date	1 Oct 1998
DOIs	https://doi.org/10.1038/sj.onc.1202103
Publication status	Published - 1 Oct 1998

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abstract = "We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.",

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T1 - Homozygous deletions at 3p12 in breast and lung cancer

AU - Sundaresan, V

AU - Chung, G

AU - Heppell-Parton, A

AU - Xiong, Jie

AU - Grundy, C

AU - Roberts, I

AU - James, L

AU - Cahn, A

AU - Douglas, J

AU - Minna, MI

AU - Sekido, Y

AU - Lerman, MI

AU - Latif, Farida

AU - Bergh, J

AU - Li, H

AU - Lowe, N

AU - Ogilvie, D

AU - Rabbitts, P

PY - 1998/10/1

Y1 - 1998/10/1

N2 - We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.

AB - We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.

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JO - Oncogene

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Homozygous deletions at 3p12 in breast and lung cancer

Abstract

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