Growth hormone and its disorders

John Ayuk, Michael Sheppard

Research output: Contribution to journalReview article

81 Citations (Scopus)


Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting postnatal longitudinal growth as well as protein, lipid, and carbohydrate metabolism. GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults. This article, aimed at non-paediatric physicians, examines the clinical features, diagnosis, and current concepts in the management of these conditions.
Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalPostgraduate Medical Journal
Issue number963
Publication statusPublished - 1 Jan 2006


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