TY - JOUR
T1 - Growth hormone and its disorders
AU - Ayuk, John
AU - Sheppard, Michael
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting postnatal longitudinal growth as well as protein, lipid, and carbohydrate metabolism. GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults. This article, aimed at non-paediatric physicians, examines the clinical features, diagnosis, and current concepts in the management of these conditions.
AB - Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting postnatal longitudinal growth as well as protein, lipid, and carbohydrate metabolism. GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults. This article, aimed at non-paediatric physicians, examines the clinical features, diagnosis, and current concepts in the management of these conditions.
UR - http://www.scopus.com/inward/record.url?scp=30944435621&partnerID=8YFLogxK
U2 - 10.1136/pgmj.2005.036087
DO - 10.1136/pgmj.2005.036087
M3 - Review article
C2 - 16397076
SN - 1469-0756
VL - 82
SP - 24
EP - 30
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
IS - 963
ER -